Maryam Tabesh1,2, Jonathan E Shaw1,2, Paul Z Zimmet1,3, Stefan Söderberg1,4, Digsu N Koye1,2, Sudhir Kowlessur5, Maryam Timol5, Noorjehan Joonas5, Ameena Sorefan5, Praneel Gayan5, K George M M Alberti6, Jaakko Tuomilehto7,8,9, Dianna J Magliano1,2. 1. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. 2. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. 3. Department of Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia. 4. Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. 5. Ministry of Health and Quality of Life, Port Louis, Mauritius. 6. Department of Endocrinology and Metabolism, St Mary's Hospital and Imperial College, London, UK. 7. Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland. 8. Dasman Diabetes Institute, Dasman, Kuwait. 9. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
Abstract
BACKGROUND: The aim of this study was to evaluate the association between type 2 diabetes and disability in Mauritius and to assess the extent to which the effect of diabetes is explained by diabetes risk factors and concomitant complications. METHODS: Data from a national survey in the multiethnic nation of Mauritius, which comprises South Asians and African Creoles, were analyzed. Disability was measured using the Katz activities of daily living questionnaire in participants aged >50 years. RESULTS: Among 3692 participants, 487 (13.2%) had some level of disability. Diabetes was associated with significantly higher risk of disability (odds ratio [OR] 1.67; 95% confidence interval [CI] 1.34-2.08). After adjusting for demographic, behavioral, and metabolic factors, as well as comorbidities, disability was significantly associated with diabetes among African Creoles (OR 2.03; 95% CI 1.16-3.56), but not South Asians (OR 1.27; 95% CI 0.98-1.66). Obesity explained much of the association between diabetes and disability (excess percentage of risk: 26.3% in South Asians and 12.1% in African Creoles). Obesity, history of cardiovascular disease (CVD), asthma-like symptoms, and depression together explained 46.5% and 29.0% of the excess risk in South Asians and African Creoles, respectively. CONCLUSIONS: Diabetes is associated with a 67% increased risk of disability. Diabetes risk factors and comorbidities explain more of the association between diabetes and disability among South Asians than Africans. Obesity and history of CVD explained the largest percentage of the relationship between diabetes and disability, indicating that weight and CVD management may be helpful in controlling disability related to diabetes.
BACKGROUND: The aim of this study was to evaluate the association between type 2 diabetes and disability in Mauritius and to assess the extent to which the effect of diabetes is explained by diabetes risk factors and concomitant complications. METHODS: Data from a national survey in the multiethnic nation of Mauritius, which comprises South Asians and African Creoles, were analyzed. Disability was measured using the Katz activities of daily living questionnaire in participants aged >50 years. RESULTS: Among 3692 participants, 487 (13.2%) had some level of disability. Diabetes was associated with significantly higher risk of disability (odds ratio [OR] 1.67; 95% confidence interval [CI] 1.34-2.08). After adjusting for demographic, behavioral, and metabolic factors, as well as comorbidities, disability was significantly associated with diabetes among African Creoles (OR 2.03; 95% CI 1.16-3.56), but not South Asians (OR 1.27; 95% CI 0.98-1.66). Obesity explained much of the association between diabetes and disability (excess percentage of risk: 26.3% in South Asians and 12.1% in African Creoles). Obesity, history of cardiovascular disease (CVD), asthma-like symptoms, and depression together explained 46.5% and 29.0% of the excess risk in South Asians and African Creoles, respectively. CONCLUSIONS:Diabetes is associated with a 67% increased risk of disability. Diabetes risk factors and comorbidities explain more of the association between diabetes and disability among South Asians than Africans. Obesity and history of CVD explained the largest percentage of the relationship between diabetes and disability, indicating that weight and CVD management may be helpful in controlling disability related to diabetes.
Authors: Yiqiao Xin; Andrew Davies; Louise McCombie; Andrew Briggs; C-Martina Messow; Eleanor Grieve; Wilma S Leslie; Roy Taylor; Michael E J Lean Journal: Lancet Diabetes Endocrinol Date: 2018-12-20 Impact factor: 32.069
Authors: Omar Yaxmehen Bello-Chavolla; Carlos Alberto Aguilar-Salinas; José Alberto Avila-Funes Journal: BMC Geriatr Date: 2020-09-22 Impact factor: 3.921