Tam Ramsey1, Eric Guo1, Peter F Svider1, Hosheng Lin1,2,3, Sara Syeda4, S Naweed Raza1,2, Andrew M Fribley1,5,6,2. 1. Department of Otolaryngology-Head and Neck Surgery, Detroit, Michigan, U.S.A. 2. Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, U.S.A. 3. John Dingell VA Medical Center, Detroit, Michigan, U.S.A. 4. Department of Economics, Wayne State University, Detroit, Michigan, U.S.A. 5. Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, U.S.A. 6. Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, U.S.A.
Abstract
OBJECTIVES/HYPOTHESIS: To characterize health burden and determine the associated level of equality of laryngeal carcinoma (LC) burden at a global level. METHODS: One hundred eighty-four countries were organized by socioeconomic status using Human Development Index (HDI) categorizations provided by the United Nations Development Program. Disability-adjusted life years (DALYs), obtained from The Global Health Data Exchange, were calculated and compared between each HDI category for the period from 1990 to 2015. Equality of LC burden was then evaluated with concentration indices. RESULTS: Global LC burden, as measured by age-standardized DALYs, has improved significantly over the 25-year period studied. This burden has declined for very high, high, and medium HDI countries, whereas it has remained unchanged for low HDI countries. The majority of LC global burden was found in high socioeconomic countries before 2010 and has shifted toward low socioeconomic countries, as indicated by concentration indices. Over the last 25 years, Central and Eastern Europe continue to have the largest disease burden in the world. CONCLUSION: This is the first analysis that we are aware of investigating health disparities of LC at a global level. The global burden of the disease has declined, which is a trend corresponding with significantly reduced smoking behaviors in developed countries. Although the global inequality gap decreased between 2010 and 2015, there remain reasons for concern. Smoking continues to trend upward in low socioeconomic countries, which could increase LC burden in low socioeconomic countries in the near future. A new global initiative directed toward low socioeconomic countries may yield dividends in preventing subsequent disparities in the LC burden. LEVEL OF EVIDENCE: 4. Laryngoscope, 128:2039-2053, 2018.
OBJECTIVES/HYPOTHESIS: To characterize health burden and determine the associated level of equality of laryngeal carcinoma (LC) burden at a global level. METHODS: One hundred eighty-four countries were organized by socioeconomic status using Human Development Index (HDI) categorizations provided by the United Nations Development Program. Disability-adjusted life years (DALYs), obtained from The Global Health Data Exchange, were calculated and compared between each HDI category for the period from 1990 to 2015. Equality of LC burden was then evaluated with concentration indices. RESULTS: Global LC burden, as measured by age-standardized DALYs, has improved significantly over the 25-year period studied. This burden has declined for very high, high, and medium HDI countries, whereas it has remained unchanged for low HDI countries. The majority of LC global burden was found in high socioeconomic countries before 2010 and has shifted toward low socioeconomic countries, as indicated by concentration indices. Over the last 25 years, Central and Eastern Europe continue to have the largest disease burden in the world. CONCLUSION: This is the first analysis that we are aware of investigating health disparities of LC at a global level. The global burden of the disease has declined, which is a trend corresponding with significantly reduced smoking behaviors in developed countries. Although the global inequality gap decreased between 2010 and 2015, there remain reasons for concern. Smoking continues to trend upward in low socioeconomic countries, which could increase LC burden in low socioeconomic countries in the near future. A new global initiative directed toward low socioeconomic countries may yield dividends in preventing subsequent disparities in the LC burden. LEVEL OF EVIDENCE: 4. Laryngoscope, 128:2039-2053, 2018.
Authors: Ian-James Malm; Lisa M Rooper; Justin A Bishop; Selmin Karatayli Ozgursoy; Alexander T Hillel; Lee M Akst; Simon R Best Journal: Am J Otolaryngol Date: 2018-11-22 Impact factor: 1.808
Authors: Priyanka Shah O'Brien; Yue Xi; Justin R Miller; Amy L Brownell; Qinghua Zeng; George H Yoo; Danielle M Garshott; Matthew B O'Brien; Anthony E Galinato; Peter Cai; Neha Narula; Michael U Callaghan; Randal J Kaufman; Andrew M Fribley Journal: J Clin Med Date: 2019-05-06 Impact factor: 4.241