Analysis of RNA Editing Sites from RNA-Seq Data Using GIREMI.

RNA editing is a posttranscriptional modification process that alters the sequence of RNA molecules. RNA editing is related to many human diseases. However, the identification of RNA editing sites typically requires matched genomic sequence or multiple related expression data sets. Here we describe the GIREMI tool (genome-independent identification of RNA editing by mutual information; https://github.com/zhqingit/giremi ) that is designed to accurately and sensitively predict adenosine-to-inosine editing from a single RNA-Seq data set.