Kah Poh Loh1, Jason Zittel1, Sindhuja Kadambi1, Chintan Pandya1, Huiwen Xu2, Marie Flannery3, Allison Magnuson1, Javier Bautista1, Colin McHugh1, Karen Mustian1, William Dale4, Paul Duberstein1, Supriya G Mohile5. 1. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, United States. 2. Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, United States. 3. School of Nursing, University of Rochester School of Medicine and Dentistry, United States. 4. Department of Medicine, Section of Geriatrics & Palliative Medicine, University of Chicago Medical Center, United States. 5. James P Wilmot Cancer Institute, University of Rochester School of Medicine and Dentistry, United States. Electronic address: supriya_mohile@urmc.rochester.edu.
Abstract
OBJECTIVES: Sleep disturbance is prevalent and often coexists with depression, fatigue, and pain in the cancer population. The aim of this study was to describe the prevalence of sleep disturbance with co-existing depression, fatigue, and pain in older patients with cancer. We also examined the associations of several socio-demographic and clinical variables with sleep disturbance. METHODS: This cross-sectional study consisted of 389 older patients with solid and hematologic malignancies who were referred to the Specialized Oncology Care & Research in the Elderly (SOCARE) clinics at the Universities of Rochester and Chicago between May 2011 and October 2015 and completed a sleep and geriatric assessment (that inquires about fatigue, pain, and depression). Multivariate logistic regression was used to identify variables associated with sleep disturbance. RESULTS: The prevalence of sleep disturbance was 40%. Of those with sleep disturbance (n = 154), 84% also had at least one of the other three symptoms (25% had one symptom, 38% had two symptoms, and 21% had three symptoms). Sleep disturbance was more likely to be reported in those with comorbidities (45% vs. 28%, P = 0.002), depression (49% vs. 36%, P = 0.015), fatigue (49% vs. 23%, P < 0.001), and pain (45% vs. 31%, P = 0.010). On multivariable analysis, only fatigue (adjusted odds ratio (AOR) 1.90, 95% CI 1.10-3.30, P = 0.020) was independently associated with sleep disturbance. CONCLUSIONS: Sleep disturbance is prevalent and often co-occurs with depression, fatigue, or pain in older patients with cancer. Fatigue was significantly associated with sleep disturbance and future studies should explore interventions that target sleep disturbance and fatigue.
OBJECTIVES:Sleep disturbance is prevalent and often coexists with depression, fatigue, and pain in the cancer population. The aim of this study was to describe the prevalence of sleep disturbance with co-existing depression, fatigue, and pain in older patients with cancer. We also examined the associations of several socio-demographic and clinical variables with sleep disturbance. METHODS: This cross-sectional study consisted of 389 older patients with solid and hematologic malignancies who were referred to the Specialized Oncology Care & Research in the Elderly (SOCARE) clinics at the Universities of Rochester and Chicago between May 2011 and October 2015 and completed a sleep and geriatric assessment (that inquires about fatigue, pain, and depression). Multivariate logistic regression was used to identify variables associated with sleep disturbance. RESULTS: The prevalence of sleep disturbance was 40%. Of those with sleep disturbance (n = 154), 84% also had at least one of the other three symptoms (25% had one symptom, 38% had two symptoms, and 21% had three symptoms). Sleep disturbance was more likely to be reported in those with comorbidities (45% vs. 28%, P = 0.002), depression (49% vs. 36%, P = 0.015), fatigue (49% vs. 23%, P < 0.001), and pain (45% vs. 31%, P = 0.010). On multivariable analysis, only fatigue (adjusted odds ratio (AOR) 1.90, 95% CI 1.10-3.30, P = 0.020) was independently associated with sleep disturbance. CONCLUSIONS:Sleep disturbance is prevalent and often co-occurs with depression, fatigue, or pain in older patients with cancer. Fatigue was significantly associated with sleep disturbance and future studies should explore interventions that target sleep disturbance and fatigue.
Authors: C Calderon; A Carmona-Bayonas; R Hernandez; B Castelo; S Varma; O Donnay; D Gomez; P Jimenez-Fonseca Journal: Clin Transl Oncol Date: 2019-02-02 Impact factor: 3.405
Authors: Komal Singh; Steven M Paul; Kord M Kober; Yvette P Conley; Fay Wright; Jon D Levine; Paule V Joseph; Christine Miaskowski Journal: J Pain Symptom Manage Date: 2019-11-02 Impact factor: 3.612
Authors: Mingxiao Yang; Kevin T Liou; Sheila N Garland; Ting Bao; Tony K W Hung; Susan Q Li; Yuelin Li; Jun J Mao Journal: NPJ Breast Cancer Date: 2021-11-30
Authors: Yufen Lin; Donald E Bailey; Sharron L Docherty; Laura S Porter; Bruce A Cooper; Steven M Paul; Marilyn J Hammer; Yvette P Conley; Jon D Levine; Christine Miaskowski Journal: Cancer Nurs Date: 2022 Mar-Apr 01 Impact factor: 2.592
Authors: Kah Poh Loh; Erika Ramsdale; Eva Culakova; Jason H Mendler; Jane L Liesveld; Kristen M O'Dwyer; Colin McHugh; Maxence Gilles; Terri Lloyd; Molly Goodman; Heidi D Klepin; Karen M Mustian; Rebecca Schnall; Supriya G Mohile Journal: JMIR Cancer Date: 2018-10-29