| Literature DB >> 2950593 |
J M Delabar, D Goldgaber, Y Lamour, A Nicole, J L Huret, J de Grouchy, P Brown, D C Gajdusek, P M Sinet.
Abstract
With the recently cloned complementary DNA probe, lambda Am4 for the chromosome 21 gene encoding brain amyloid polypeptide (beta amyloid protein) of Alzheimer's disease, leukocyte DNA from three patients with sporadic Alzheimer's disease and two patients with karyotypically normal Down syndrome was found to contain three copies of this gene. Because a small region of chromosome 21 containing the ets-2 gene is duplicated in patients with Alzheimer's disease, as well as in karyotypically normal Down syndrome, duplication of a subsection of the critical segment of chromosome 21 that is duplicated in Down syndrome may be the genetic defect in Alzheimer's disease.Entities:
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Year: 1987 PMID： 2950593 DOI： 10.1126/science.2950593
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728