Julien Puntonet1, Volodia Dangouloff-Ros2, Raphaël Saffroy3, Mélanie Pagès1, Felipe Andreiuolo1, Jacques Grill4, Stéphanie Puget5, Nathalie Boddaert6, Pascale Varlet1. 1. Department of Pathology, Sainte-Anne Hospital, université Paris-Descartes, U1000, France. 2. Department of Pediatric Radiology, hôpital Necker-Enfants Malades, AP-HP, 149, rue de Sèvres, 75015 Paris, France; Université René-Descartes, Paris, France; Inserm U1000, Paris, France. Electronic address: volodia.dangouloff-ros@aphp.fr. 3. Department of Biochemistry, hôpital Paul-Brousse, AP-HP, Villejuif, France. 4. Department of Pediatric Oncology, Gustave-Roussy Institute, Villejuif, Paris, France. 5. Université René-Descartes, Paris, France; Department of Neurosurgery, hôpital Necker-Enfants Malades, université Paris-Descartes, Paris, France. 6. Department of Pediatric Radiology, hôpital Necker-Enfants Malades, AP-HP, 149, rue de Sèvres, 75015 Paris, France; Université René-Descartes, Paris, France; Inserm U1000, Paris, France.
Abstract
BACKGROUND AND PURPOSE: Molecular alterations were recently added to the World Health Organization (WHO) 2016 classification of central nervous system (CNS) tumors. We correlated the histological and radiological features of G34R mutant high-grade gliomas, a recently described hemispheric and supratentorial glioma of children and young adults. MATERIALS AND METHODS: We performed a retrospective multicenter study on the histopathological and MRI results of 12 patients. RESULTS: All tumors were supratentorial. Several radiological aspects were observed. Height over 12 were bulky and well delineated tumors, without visible peritumoral infiltration on MRI and pathologically characterized by highly cellular tissue associated with a moderate peritumoral infiltrative component. Two tumors were ill-defined and hyperintense on T2 sequences and pathologically characterized by diffuse tumoral infiltration. Two tumors were bulky and well delineated with an infiltrative component, both radiologically and histopathologically. CONCLUSIONS: These different patterns may correspond to different pathological mechanisms and a potential link with prognosis should be assessed in further studies.
BACKGROUND AND PURPOSE: Molecular alterations were recently added to the World Health Organization (WHO) 2016 classification of central nervous system (CNS) tumors. We correlated the histological and radiological features of G34R mutant high-grade gliomas, a recently described hemispheric and supratentorial glioma of children and young adults. MATERIALS AND METHODS: We performed a retrospective multicenter study on the histopathological and MRI results of 12 patients. RESULTS: All tumors were supratentorial. Several radiological aspects were observed. Height over 12 were bulky and well delineated tumors, without visible peritumoral infiltration on MRI and pathologically characterized by highly cellular tissue associated with a moderate peritumoral infiltrative component. Two tumors were ill-defined and hyperintense on T2 sequences and pathologically characterized by diffuse tumoral infiltration. Two tumors were bulky and well delineated with an infiltrative component, both radiologically and histopathologically. CONCLUSIONS: These different patterns may correspond to different pathological mechanisms and a potential link with prognosis should be assessed in further studies.