Minchao Li1,2,3, Liubao Gu1,3, Jun Yang1,3, Qinglin Lou1,4. 1. Center for Diabetes Care, Education and Research, Jiangsu Province Institute of Geriatrics, Nanjing, China. 2. Pukou Hospital of Traditional Chinese Medicine, Nanjing, China. 3. Division of Clinical Epidemiology, Jiangsu Province Institute of Geriatrics, Nanjing, China. 4. Department of Endocrinology and Metabolism, Jiangsu Province Official Hospital, Nanjing, China.
Abstract
BACKGROUND: The correlation between serum uric acid (SUA) and β-cell function remains controversial. The present study aims to use a new index, renal function-normalized SUA, to observe its correlation with β-cell function in patients with type 2 diabetes (T2DM). METHODS: A total of 713 patients with T2DM received standard 75-g oral glucose tolerance and insulin release test. Renal function-normalized SUA was calculated using SUA/creatinine and β-cell function was assessed by HOMA-B. Binary logistic regression analysis was used to estimate the association between SUA/creatinine and β-cell function. RESULTS: There are positive correlations between SUA/creatinine and HOMA-B (r = 0.143, P < 0.001), as well as other indexes of β-cell function including modified β-cell function index (r = 0.104, P = 0.007), InsAUC30 (r = 0.100, P = 0.008), and InsAUC120 (r = 0.124, P = 0.001). SUA/creatinine also positively correlates with insulin resistance (HOMA-IR: r = 0.161, P < 0.001). Moreover, multivariate analysis revealed that SUA/creatinine was significantly associated with preserved β-cell function, independently of potential confounders including sex, BMI, and renal function. CONCLUSIONS: SUA to creatinine ratio correlates with β-cell function in T2DM patients.
BACKGROUND: The correlation between serum uric acid (SUA) and β-cell function remains controversial. The present study aims to use a new index, renal function-normalized SUA, to observe its correlation with β-cell function in patients with type 2 diabetes (T2DM). METHODS: A total of 713 patients with T2DM received standard 75-g oral glucose tolerance and insulin release test. Renal function-normalized SUA was calculated using SUA/creatinine and β-cell function was assessed by HOMA-B. Binary logistic regression analysis was used to estimate the association between SUA/creatinine and β-cell function. RESULTS: There are positive correlations between SUA/creatinine and HOMA-B (r = 0.143, P < 0.001), as well as other indexes of β-cell function including modified β-cell function index (r = 0.104, P = 0.007), InsAUC30 (r = 0.100, P = 0.008), and InsAUC120 (r = 0.124, P = 0.001). SUA/creatinine also positively correlates with insulin resistance (HOMA-IR: r = 0.161, P < 0.001). Moreover, multivariate analysis revealed that SUA/creatinine was significantly associated with preserved β-cell function, independently of potential confounders including sex, BMI, and renal function. CONCLUSIONS:SUA to creatinine ratio correlates with β-cell function in T2DM patients.
Authors: Noha A Yousri; Karsten Suhre; Esraa Yassin; Alya Al-Shakaki; Amal Robay; Maha Elshafei; Omar Chidiac; Steven C Hunt; Ronald G Crystal; Khalid A Fakhro Journal: Diabetes Date: 2022-02-01 Impact factor: 9.461