Literature DB >> 29504097

Changes in Canonical β-Catenin/Wnt Signaling Activation in the Adrenal Cortex of Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Prenatal and Postnatal Ontogeny.

D A Tsomartova1, N V Yaglova2, V V Yaglov1.   

Abstract

Prenatal and postnatal exposure to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane (DDT) leads to delayed activation of the canonical β-catenin/Wnt signaling in zona glomerulosa and zona reticularis of the adrenal cortex in rats, which changed the rate of their postnatal development. Suppression of the Wnt pathway in zona fasciculata promotes its regeneration after DDT-induced blood circulation disorders and cell death.

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Keywords:  DDT; Wnt signaling; adrenal; endocrine disruptors; β-catenin

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Year:  2018        PMID： 29504097     DOI： 10.1007/s10517-018-4019-8

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  1 in total

1.  Developmental Exposure to Endocrine Disrupter DDT Interferes with Age-Related Involution of Thymus.

Authors:  Nataliya V Yaglova; Sergey S Obernikhin; Elina S Tsomartova; Valentin V Yaglov; Svetlana V Nazimova; Dibakhan A Tsomartova; Ekaterina P Timokhina; Elizaveta V Chereshneva; Marina Y Ivanova; Olga V Payushina
Journal:  Int J Mol Sci       Date:  2022-06-15       Impact factor: 6.208
  1 in total

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