Isheeta Zalpuri1, Manpreet K Singh1. 1. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA.
Abstract
PURPOSE OF REVIEW: Bipolar disorder is highly familial and has a protracted and diagnostically confusing prodrome. This review critically evaluates recently published literature relevant to the treatment of psychiatric symptoms in high-risk offspring of parents with Bipolar Disorder. RECENT FINDINGS: Non-pharmacological treatment options including psychotherapy, resilience promotion through good sleep, diet, and exercise hygiene, and omega-3 fatty acid supplementation are important first line interventions for high-risk offspring. There has been some success in treating this population with open-label trials with mood stabilizers and atypical antipsychotics; however, these results have not been replicated in randomized controlled trails. SUMMARY: Despite some progress in early identification of symptoms in offspring of parents with Bipolar Disorder, there is scarce evidence supporting the treatment of these high-risk youth to prevent psychiatric symptoms from progressing to threshold bipolar or other psychiatric disorders. There is a need for prospective and randomized trials and research that identifies reliable biomarkers to individualize treatments for these youth.
PURPOSE OF REVIEW: Bipolar disorder is highly familial and has a protracted and diagnostically confusing prodrome. This review critically evaluates recently published literature relevant to the treatment of psychiatric symptoms in high-risk offspring of parents with Bipolar Disorder. RECENT FINDINGS: Non-pharmacological treatment options including psychotherapy, resilience promotion through good sleep, diet, and exercise hygiene, and omega-3 fatty acid supplementation are important first line interventions for high-risk offspring. There has been some success in treating this population with open-label trials with mood stabilizers and atypical antipsychotics; however, these results have not been replicated in randomized controlled trails. SUMMARY: Despite some progress in early identification of symptoms in offspring of parents with Bipolar Disorder, there is scarce evidence supporting the treatment of these high-risk youth to prevent psychiatric symptoms from progressing to threshold bipolar or other psychiatric disorders. There is a need for prospective and randomized trials and research that identifies reliable biomarkers to individualize treatments for these youth.
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Authors: Amy S Garrett; David J Miklowitz; Meghan E Howe; Manpreet K Singh; Tenah K Acquaye; Christopher G Hawkey; Gary H Glover; Allan L Reiss; Kiki D Chang Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2014-10-02 Impact factor: 5.067
Authors: Manpreet K Singh; Akua F Nimarko; Amy S Garrett; Aaron J Gorelik; Donna J Roybal; Patricia D Walshaw; Kiki D Chang; David J Miklowitz Journal: J Am Acad Child Adolesc Psychiatry Date: 2020-08-01 Impact factor: 8.829