Marko Popovic1, Matthew B Schlenker1, Xavier Campos-Möller1, Austin Pereira1, Iqbal Ike K Ahmed2. 1. From the Faculty of Medicine (Popovic, Pereira) and the Department of Ophthalmology and Vision Sciences (Schlenker, Campos-Möller, Ahmed), University of Toronto, Toronto, and Prism Eye Institute (Campos-Möller, Ahmed) and the Department of Ophthalmology (Ahmed), Trillium Health Partners, Mississauga, Ontario, Canada. 2. From the Faculty of Medicine (Popovic, Pereira) and the Department of Ophthalmology and Vision Sciences (Schlenker, Campos-Möller, Ahmed), University of Toronto, Toronto, and Prism Eye Institute (Campos-Möller, Ahmed) and the Department of Ophthalmology (Ahmed), Trillium Health Partners, Mississauga, Ontario, Canada. Electronic address: ike.ahmed@utoronto.ca.
Abstract
PURPOSE: To externally validate the Wang-Koch method for optimization of intraocular lens (IOL) formulas. SETTING: TLC Laser Eye Centre, Mississauga, Ontario, Canada. DESIGN: Retrospective case series. METHODS: Consecutive cataract patients with an axial length (AL) of 25.0 mm or longer were recruited. The predicted postoperative spherical equivalents (SEs) calculated from the Holladay 1 formula were compared with the 3-week postoperative SEs to yield prediction errors for Wang-Koch adjusted and unadjusted ALs. A mixed linear model was used to compare the proportion of eyes with a prediction error of ±0.25 diopter (D) or worse, ±0.50 D or worse, and ±1.00 D or worse between groups. The secondary outcomes of mean absolute error and median absolute error were also analyzed. A subgroup analysis was performed based on AL subgroups. RESULTS: Two hundred sixty-two eyes were selected for inclusion with a balanced sex distribution, a mean age of 62.49 years ± 9.13 (SD), and a preoperative AL of 26.49 ± 1.10 mm. Subgroup prediction error comparisons of ±0.50 D or worse favored unadjusted eyes with ALs between 25.0 mm and 26.0 mm (n = 105; P < .001), no difference in eyes with ALs between 26.0 mm and 27.0 mm (n = 91; P = .43), adjusted eyes with ALs between 27.0 mm and 28.0 mm (n = 36; P = .003), and adjusted eyes with ALs of 28.00 mm or longer (n = 30; P < .001). CONCLUSION: The Wang-Koch adjustment should only be applied in eyes with ALs longer than 27.0 mm that have IOL power calculation with the Holladay 1 formula.
PURPOSE: To externally validate the Wang-Koch method for optimization of intraocular lens (IOL) formulas. SETTING: TLC Laser Eye Centre, Mississauga, Ontario, Canada. DESIGN: Retrospective case series. METHODS: Consecutive cataractpatients with an axial length (AL) of 25.0 mm or longer were recruited. The predicted postoperative spherical equivalents (SEs) calculated from the Holladay 1 formula were compared with the 3-week postoperative SEs to yield prediction errors for Wang-Koch adjusted and unadjusted ALs. A mixed linear model was used to compare the proportion of eyes with a prediction error of ±0.25 diopter (D) or worse, ±0.50 D or worse, and ±1.00 D or worse between groups. The secondary outcomes of mean absolute error and median absolute error were also analyzed. A subgroup analysis was performed based on AL subgroups. RESULTS: Two hundred sixty-two eyes were selected for inclusion with a balanced sex distribution, a mean age of 62.49 years ± 9.13 (SD), and a preoperative AL of 26.49 ± 1.10 mm. Subgroup prediction error comparisons of ±0.50 D or worse favored unadjusted eyes with ALs between 25.0 mm and 26.0 mm (n = 105; P < .001), no difference in eyes with ALs between 26.0 mm and 27.0 mm (n = 91; P = .43), adjusted eyes with ALs between 27.0 mm and 28.0 mm (n = 36; P = .003), and adjusted eyes with ALs of 28.00 mm or longer (n = 30; P < .001). CONCLUSION: The Wang-Koch adjustment should only be applied in eyes with ALs longer than 27.0 mm that have IOL power calculation with the Holladay 1 formula.