| Literature DB >> 29502438 |
Lu Liu1,2, Ming-Xu Tang1,2, Xia-Nan Sang1,2, Shao-Fei Chen1,2, Xiao-Jie Lu1,2, Yu-Bo Wang3, Ying-Ying Si1,2, Hai-Feng Wang1,2, Gang Chen4, Yue-Hu Pei4.
Abstract
Three new tetralol analogs, myrochromanols A-C (1-3), together with 11 known trichothecenes (4-14), were isolated from a soil fungus Myrothecium verrucaria HL-P-1. The structures of the three new compounds were elucidated by extensive spectroscopic analysis including HRESIMS, NMR, and ECD calculation. All of the new compounds were tested for their anti-inflammatory activity and cytotoxicity. Compounds 1 and 3 inhibited lipopolysaccharide (LPS)-induced NO production in BV2 cells with IC50 values of 26.04 and 25.80 μM, respectively.Entities:
Keywords: Tetralol analogs; anti-inflammation; cytotoxicity
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Year: 2018 PMID： 29502438 DOI： 10.1080/10286020.2018.1439934
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569