Luigino Dal Maso1, Chiara Panato2, Silvia Franceschi3, Diego Serraino2, Carlotta Buzzoni4, Susanna Busco5, Stefano Ferretti6, Antonietta Torrisi7, Fabio Falcini8, Manuel Zorzi9, Claudia Cirilli10, Walter Mazzucco11, Michele Magoni12, Paolo Collarile2, Fabio Pannozzo5, Anna Luisa Caiazzo13, Antonio Giampiero Russo14, Alessio Gili15, Adele Caldarella16, Roberto Zanetti17, Maria Michiara18, Lucia Mangone19, Rosa Angela Filiberti20, Mario Fusco21, Francesca Gasparini6, Giovanna Tagliabue22, Rosaria Cesaraccio23, Rosario Tumino24, Luciana Gatti25, Francesco Tisano26, Silvano Piffer27, Giovanna Maria Sini28, Guido Mazzoleni29, Stefano Rosso30, Anna Clara Fanetti31, Salvatore Vaccarella3. 1. Cancer Epidemiology Unit, CRO Aviano National Cancer Institute IRCCS, Aviano, Italy. Electronic address: epidemiology@cro.it. 2. Cancer Epidemiology Unit, CRO Aviano National Cancer Institute IRCCS, Aviano, Italy. 3. International Agency for Research on Cancer, Lyon, France. 4. Tuscany Cancer Registry, Clinical and Descriptive Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy; AIRTUM Database, Florence, Italy. 5. Cancer Registry of Latina Province, ASL Latina, Italy. 6. Ferrara Cancer Registry, University of Ferrara, Azienda USL Ferrara, Italy. 7. Registro Tumori Integrato Catania-Messina-Siracusa-Enna, Università Degli Studi di Catania, Italy. 8. Romagna Cancer Registry, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola (Forlì), Italy-Azienda Usl della Romagna, Forlì, Italy. 9. Veneto Tumor Registry, Veneto Region, Padua, Italy. 10. Modena Cancer Registry, Public Health Department, AUSL Modena, Italy. 11. Palermo and Province Cancer Registry, Clinical Epidemiology Unit with Cancer Registry, Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone", University of Palermo, Italy. 12. Brescia Cancer Registry, Epidemiology Unit, Brescia Health Protection Agency, Italy. 13. ASL Salerno Cancer Registry, Salerno, Italy. 14. Cancer Registry of Milan, Epidemiology Unit, Agency for Health Protection of Milan, Italy. 15. Public Health Section, Dept. of Experimental Medicine, University of Perugia, Italy. 16. Tuscany Cancer Registry, Clinical and Descriptive Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence, Italy. 17. Piedmont Cancer Registry, City of Torino, Ospedale S. Giovanni Battista-CPO, Torino, Italy. 18. Parma Cancer Registry, Oncology Unit, Azienda Ospedaliera Universitaria di Parma, Italy. 19. Reggio Emilia Cancer Registry, Epidemiology Unit, AUSL ASMN-IRCCS, Azienda USL di Reggio Emilia, Italy. 20. Liguria Region Cancer Registry, Epidemiologia Clinica, Ospedale Policlinico San Martino IRCCS, Genova, Italy. 21. Cancer Registry of ASL Napoli 3 Sud, Napoli, Italy. 22. Lombardy Cancer Registry, Varese Province, Cancer Registry Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. 23. North Sardinia Cancer Registry, Azienda Regionale per la Tutela della Salute, Sassari, Italy. 24. Cancer Registry and Histopathology Department, "Civic - M.P. Arezzo" Hospital, ASP Ragusa, Italy. 25. Mantova Cancer Registry, Epidemilogy Unit, Agenzia di Tutela Della Salute (ATS) Della Val Padana, Mantova, Italy. 26. Cancer Registry of the Province of Siracusa, Local Health Unit of Siracusa, Italy. 27. Trento Province Cancer Registry, Unit of Clinical Epidemiology, Trento, Italy. 28. Nuoro Cancer Registry, RT Nuoro, ASSL Nuoro/ATS Sardegna, Nuoro, Italy. 29. Southtyrol Cancer Registry, Bolzano, Italy. 30. Piedmont Cancer Registry, Biella Province, Biella, Italy. 31. Sondrio Cancer Registry, Health Protection Agency, Sondrio, Italy.
Abstract
AIMS: In Italy, incidence rates of thyroid cancer (TC) are among the highest worldwide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attributable to overdiagnosis. METHODS: Data on TC cases reported to Italian cancer registries during 1998-2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region. RESULTS: In Italy between 1998-2002 and 2008-2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (+91% in women, +120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998-2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008-2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders. CONCLUSION(S): Incidence rates of TC are steadily increasing in Italy and largely due to overdiagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.
AIMS: In Italy, incidence rates of thyroid cancer (TC) are among the highest worldwide with substantial intracountry heterogeneity. The aim of the study was to examine time trends of TC incidence in Italy and to estimate the proportion of TC cases potentially attributable to overdiagnosis. METHODS: Data on TC cases reported to Italian cancer registries during 1998-2012 aged <85 years were included. Age-standardised incidence rates (ASR) were computed by sex, period, and histology. TC overdiagnosis was estimated by sex, period, age, and Italian region. RESULTS: In Italy between 1998-2002 and 2008-2012, TC ASR increased of 74% in women (from 16.2 to 28.2/100,000) and of 90% in men (from 5.3 to 10.1/100,000). ASR increases were nearly exclusively due to papillary TC (+91% in women, +120% in men). In both sexes, more than three-fold differences emerged between regions with highest and lowest ASR. Among TC cases diagnosed in 1998-2012 in Italy, we estimated that overdiagnosis accounted for 75% of cases in women and 63% in men and increased over the study period leading to overdiagnosis of 79% in women and 67% in men in 2008-2012. Notably, overdiagnosis was over 80% among women aged <55 years, and substantial variations were documented across Italian regions, in both genders. CONCLUSION(S): Incidence rates of TC are steadily increasing in Italy and largely due to overdiagnosis. These findings call for an update of thyroid gland examination practices in the asymptomatic general population, at national and regional levels.
Authors: L Dal Maso; C Panato; A De Paoli; V Mattioli; D Serraino; R Elisei; G Zoppini; C Gobitti; E Borsatti; E Di Felice; F Falcini; S Ferretti; S Francisci; P Giorgi Rossi; S Guzzinati; G Mazzoleni; D Pierannunzio; S Piffer; S Vaccarella; M Vicentini; M Zorzi; S Franceschi; U Fedeli Journal: J Endocrinol Invest Date: 2021-01-18 Impact factor: 4.256
Authors: Claudio Costantino; Walter Mazzucco; Vincenzo Restivo; Ida Iolanda Mura; Gaetano Maria Fara; Giuseppe Giammanco; Sabrina Vecchio Verderame; Giuseppe Alessio Messano; Carmelo Massimo Maida; Alessandra Casuccio; Francesco Vitale Journal: Front Public Health Date: 2020-07-23
Authors: Francesca Gorini; Giorgio Iervasi; Alessio Coi; Letizia Pitto; Fabrizio Bianchi Journal: Int J Environ Res Public Health Date: 2018-08-24 Impact factor: 3.390