Lu Shen1, Guoxing Zhou1, Tong Tong2, Fei Tang1, Yi Lin1, Jie Zhou1, Yibin Wang1, Genlin Zong1, Lei Zhang3. 1. Department of Radiology, East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. 2. Department of Radiology, Shanghai Cancer Center, School of Medicine, Fudan University, Shanghai, 200032, China. 3. Department of Radiology, East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. Electronic address: zl1312@easthospital.cn.
Abstract
PURPOSE: To investigate the role of apparent diffusion coefficient (ADC) as an imaging biomarker for invasive ductal carcinoma (IDC) in the breast. METHODS: Seventy-one patients undergoing 3.0 Tesla DWI were retrospectively enrolled. Correlations between the ADC values and prognostic factors were evaluated. RESULTS: Multivariate regression analyses showed that Ki67 expression and molecular subtype were independently associated with the ADC. Discriminant analysis excluded the ADC as a good biomarker for subtype, but the mean ADC significantly distinguished Ki67-positive (low ADC) from Ki67-negative (high ADC) lesions, as observed in the in ROC curves, with a diagnostic sensitivity of 1.00 and a cut-off value of 0.97 × 10-3 mm2/s. CONCLUSION: The ADC may be helpful for predicting Ki67 expression in IDC preoperatively.
PURPOSE: To investigate the role of apparent diffusion coefficient (ADC) as an imaging biomarker for invasive ductal carcinoma (IDC) in the breast. METHODS: Seventy-one patients undergoing 3.0 Tesla DWI were retrospectively enrolled. Correlations between the ADC values and prognostic factors were evaluated. RESULTS: Multivariate regression analyses showed that Ki67 expression and molecular subtype were independently associated with the ADC. Discriminant analysis excluded the ADC as a good biomarker for subtype, but the mean ADC significantly distinguished Ki67-positive (low ADC) from Ki67-negative (high ADC) lesions, as observed in the in ROC curves, with a diagnostic sensitivity of 1.00 and a cut-off value of 0.97 × 10-3 mm2/s. CONCLUSION: The ADC may be helpful for predicting Ki67 expression in IDC preoperatively.