Tomoaki Suzuki1, Tohru Asai2, Takeshi Kinoshita2. 1. Department of Cardiovascular Surgery, Shiga University of Medical Science, Shiga, Japan. Electronic address: suzukit@belle.shiga-med.ac.jp. 2. Department of Cardiovascular Surgery, Shiga University of Medical Science, Shiga, Japan.
Abstract
BACKGROUND: It is impossible to resolve all the problems of the entire diseased aorta with just one operation for acute type A aortic dissection, which requires additional surgical treatment in the long-term. METHODS: From April 2004 to March 2017, 310 patients underwent surgical repair for acute type A aortic dissection at our institution. Of these, 32 (10.3%) died in the hospital. Of the 278 hospital survivors, 38 underwent late reoperation associated with aortic dissection during the follow-up period. We compared the 240 nonreoperation patients and the 38 reoperation patients to analyze risk factors for late reoperation after operations for acute type A dissection. RESULTS: The mean duration from the initial operation to reoperation was 3.54 ± 3.0 years. The rates of actuarial freedom from reoperation were 96.9%, 83.2%, and 64.2% at 1, 5, and 10 years, respectively. The multivariate Cox proportional hazard regression analysis revealed the following as independent predictors of late reoperation: younger age, Marfan syndrome, nonprescription of β-blockers, greater diameter of the descending aorta, ratio of false lumen to true lumen of more than 1, limb malperfusion, and primary entry in the ascending aorta. Log-rank analysis revealed no difference in long-term survival between the two groups. CONCLUSIONS: We found several risk factors for both late reoperation and death. Specifically, aortic diameter in the early phase after the initial operation and nonuse of β-blockers were strong predictors. The ratio of the false lumen to the true lumen may also be a new and useful indicator for late reoperation.
BACKGROUND: It is impossible to resolve all the problems of the entire diseased aorta with just one operation for acute type A aortic dissection, which requires additional surgical treatment in the long-term. METHODS: From April 2004 to March 2017, 310 patients underwent surgical repair for acute type A aortic dissection at our institution. Of these, 32 (10.3%) died in the hospital. Of the 278 hospital survivors, 38 underwent late reoperation associated with aortic dissection during the follow-up period. We compared the 240 nonreoperation patients and the 38 reoperation patients to analyze risk factors for late reoperation after operations for acute type A dissection. RESULTS: The mean duration from the initial operation to reoperation was 3.54 ± 3.0 years. The rates of actuarial freedom from reoperation were 96.9%, 83.2%, and 64.2% at 1, 5, and 10 years, respectively. The multivariate Cox proportional hazard regression analysis revealed the following as independent predictors of late reoperation: younger age, Marfan syndrome, nonprescription of β-blockers, greater diameter of the descending aorta, ratio of false lumen to true lumen of more than 1, limb malperfusion, and primary entry in the ascending aorta. Log-rank analysis revealed no difference in long-term survival between the two groups. CONCLUSIONS: We found several risk factors for both late reoperation and death. Specifically, aortic diameter in the early phase after the initial operation and nonuse of β-blockers were strong predictors. The ratio of the false lumen to the true lumen may also be a new and useful indicator for late reoperation.
Authors: Elizabeth L Norton; David M Williams; Karen M Kim; Minhaj S Khaja; Xiaoting Wu; Himanshu J Patel; G Michael Deeb; Bo Yang Journal: J Thorac Cardiovasc Surg Date: 2019-09-30 Impact factor: 5.209
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