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Literature DB >> 29501211

Addressing the Opioid Crisis: The Importance of Choosing Translational Endpoints in Analgesic Drug Discovery.

Abstract

The opioid crisis has stimulated renewed interest in analgesic drug development. This effort will involve preclinical-to-clinical translational research and will benefit from a focus on endpoints that are both clinically relevant and shared across laboratory animals and humans. Measures of pain-related functional impairment and behavioral depression could serve this purpose.

Entities: Chemical Disease Gene Species

Keywords: analgesic; drug development; opioid; pain; translation

Mesh：

Substances：

Year: 2018 PMID： 29501211 PMCID： PMC5869150 DOI： 10.1016/j.tips.2018.02.002

Source DB: PubMed Journal: Trends Pharmacol Sci ISSN： 0165-6147 Impact factor: 14.819

15 in total

1. An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee.

Authors: John P Huggins; Trevor S Smart; Stephen Langman; Louise Taylor; Tim Young
Journal: Pain Date: 2012-06-21 Impact factor: 6.961

Review 2. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations.

Authors: Robert H Dworkin; Dennis C Turk; John T Farrar; Jennifer A Haythornthwaite; Mark P Jensen; Nathaniel P Katz; Robert D Kerns; Gerold Stucki; Robert R Allen; Nicholas Bellamy; Daniel B Carr; Julie Chandler; Penney Cowan; Raymond Dionne; Bradley S Galer; Sharon Hertz; Alejandro R Jadad; Lynn D Kramer; Donald C Manning; Susan Martin; Cynthia G McCormick; Michael P McDermott; Patrick McGrath; Steve Quessy; Bob A Rappaport; Wendye Robbins; James P Robinson; Margaret Rothman; Mike A Royal; Lee Simon; Joseph W Stauffer; Wendy Stein; Jane Tollett; Joachim Wernicke; James Witter
Journal: Pain Date: 2005-01 Impact factor: 6.961

3. The Role of Science in Addressing the Opioid Crisis.

Authors: Nora D Volkow; Francis S Collins
Journal: N Engl J Med Date: 2017-05-31 Impact factor: 91.245

4. Report of the NIH Task Force on research standards for chronic low back pain.

Authors: Richard A Deyo; Samuel F Dworkin; Dagmar Amtmann; Gunnar Andersson; David Borenstein; Eugene Carragee; John Carrino; Roger Chou; Karon Cook; Anthony DeLitto; Christine Goertz; Partap Khalsa; John Loeser; Sean Mackey; James Panagis; James Rainville; Tor Tosteson; Dennis Turk; Michael Von Korff; Debra K Weiner
Journal: J Pain Date: 2014-04-29 Impact factor: 5.820

Review 5. NK1 (substance P) receptor antagonists--why are they not analgesic in humans?

Authors: R Hill
Journal: Trends Pharmacol Sci Date: 2000-07 Impact factor: 14.819

Review 6. Preclinical Pharmacological Approaches in Drug Discovery for Chronic Pain.

Authors: Garth T Whiteside; James D Pomonis; Jeffrey D Kennedy
Journal: Adv Pharmacol Date: 2016-01-21

7. Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies.

Authors: Marie T Fallon; Eberhard Albert Lux; Robert McQuade; Sandro Rossetti; Raymond Sanchez; Wei Sun; Stephen Wright; Aron H Lichtman; Elena Kornyeyeva
Journal: Br J Pain Date: 2017-05-17

8. Analgesic efficacy of the kappa-receptor agonist, enadoline, in dental surgery pain.

Authors: A C Pande; R E Pyke; M Greiner; S A Cooper; R Benjamin; M W Pierce
Journal: Clin Neuropharmacol Date: 1996-02 Impact factor: 1.592

Review 9. Expression and treatment of pain-related behavioral depression.

Authors: S Stevens Negus
Journal: Lab Anim (NY) Date: 2013-08 Impact factor: 12.625

10. Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice.

Authors: S Stevens Negus; Bradley Neddenriep; Ahmad A Altarifi; F Ivy Carroll; Michael D Leitl; Laurence L Miller
Journal: Pain Date: 2015-06 Impact factor: 7.926

9 in total

1. Developing Improved Translational Models of Pain: A Role for the Behavioral Scientist.

Authors: Sarah L Withey; David R Maguire; Brian D Kangas
Journal: Perspect Behav Sci Date: 2020-01-03

Review 2. Brain circuits for pain and its treatment.

Authors: Nicole Mercer Lindsay; Chong Chen; Gadi Gilam; Sean Mackey; Grégory Scherrer
Journal: Sci Transl Med Date: 2021-11-10 Impact factor: 17.956

3. Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models.

Authors: Karen M Wagner; Jogen Atone; Bruce D Hammock
Journal: Brain Res Date: 2019-11-29 Impact factor: 3.252

4. Composition of nutrient media and temperature of cultivation imposes effect on the content of secondary metabolites of Nocardiopsis sp. isolated from a Siberian Cave.

Authors: Denis V Axenov-Gribanov; Maria M Morgunova; Ulyana A Vasilieva; Stanislav V Gamaiunov; Maria E Dmitrieva Krasnova; Ekaterina V Pereliaeva; Alexander Yu Belyshenko; Andriy N Luzhetskyy
Journal: 3 Biotech Date: 2021-07-28 Impact factor: 2.893

Review 5. The Na_V1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons.

Authors: Tânia C Gonçalves; Evelyne Benoit; Michel Partiseti; Denis Servent
Journal: Front Pharmacol Date: 2018-09-04 Impact factor: 5.810

6. Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation.

Authors: Ángeles Montilla-García; Miguel Á Tejada; M Carmen Ruiz-Cantero; Inmaculada Bravo-Caparrós; Sandra Yeste; Daniel Zamanillo; Enrique J Cobos
Journal: Front Pharmacol Date: 2019-02-22 Impact factor: 5.810

Addressing the Opioid Crisis: The Importance of Choosing Translational Endpoints in Analgesic Drug Discovery.

1. An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee.

Review 2. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations.

3. The Role of Science in Addressing the Opioid Crisis.

4. Report of the NIH Task Force on research standards for chronic low back pain.

Review 5. NK1 (substance P) receptor antagonists--why are they not analgesic in humans?

Review 6. Preclinical Pharmacological Approaches in Drug Discovery for Chronic Pain.

7. Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies.

8. Analgesic efficacy of the kappa-receptor agonist, enadoline, in dental surgery pain.

Review 9. Expression and treatment of pain-related behavioral depression.

10. Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice.

1. Developing Improved Translational Models of Pain: A Role for the Behavioral Scientist.

Review 2. Brain circuits for pain and its treatment.

3. Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models.

4. Composition of nutrient media and temperature of cultivation imposes effect on the content of secondary metabolites of Nocardiopsis sp. isolated from a Siberian Cave.

Review 5. The Na_V1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons.

6. Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation.

7. Evaluation of the Spider (Phlogiellus genus) Phlotoxin 1 and Synthetic Variants as Antinociceptive Drug Candidates.

Review 8. Effective Oriental Magic for Analgesia: Acupuncture.

9. Comparative benefits of social housing and buprenorphine on wheel running depressed by morphine withdrawal in rats.

Review 2. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations.

Review 5. NK1 (substance P) receptor antagonists--why are they not analgesic in humans?

Review 6. Preclinical Pharmacological Approaches in Drug Discovery for Chronic Pain.

Review 9. Expression and treatment of pain-related behavioral depression.

Review 2. Brain circuits for pain and its treatment.

Review 5. The NaV1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons.

Review 8. Effective Oriental Magic for Analgesia: Acupuncture.

Review 5. The Na_V1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons.