| Literature DB >> 29498825 |
Haihong He1, Yang Xia1, Yingxue Qi1, Hong-Yin Wang2, Zhuang Wang1, Jianming Bao3, Ziqian Zhang4, Fu-Gen Wu2, Haolu Wang5, Daijie Chen6, Dahai Yang1, Xiaowen Liang5, Jinquan Chen7, Shengmin Zhou1, Xin Liang1, Xuhong Qian1, Youjun Yang1.
Abstract
Nitric oxide (NO) is a versatile endogenous molecule, involved in various physiological processes and implicated in the progression of many pathological conditions. Therefore, NO donors are valuable tools in NO related basic and applied applications. The traditional spontaneous NO donors are limited in scenarios where flux, localization, and dose of NO could be monitored. This has promoted the development of novel NO donors, whose NO release is not only under control, but also self-calibrated. Herein, we reported a phototriggered and photocalibrated NO donor (NOD565) with an N-nitroso group on a rhodamine dye. NOD565 is nonfluorescent and could release NO efficiently upon irradiation by green light. A bright rhodamine dye is generated as a side-product and its fluorescence can be used to monitor the NO release. The potentials of NOD565 in practical applications are showcased in in vitro studies, e.g., platelet aggregation inhibition and fungi growth suppression.Entities:
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Year: 2018 PMID： 29498825 DOI： 10.1021/acs.bioconjchem.7b00821
Source DB: PubMed Journal: Bioconjug Chem ISSN： 1043-1802 Impact factor: 4.774