Erin E Cook1,2, Susan T Gershman3, Jane J Kim4, Rulla M Tamimi5,6, R Monina Klevens7, Michelle D Holmes5,6. 1. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. eeo854@mail.harvard.edu. 2. Massachusetts Cancer Registry, Massachusetts Department of Public Health, Boston, USA. eeo854@mail.harvard.edu. 3. Massachusetts Cancer Registry, Massachusetts Department of Public Health, Boston, USA. 4. Department of Health Policy and Management, Harvard T. H. Chan School of Public Health, Boston, USA. 5. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. 6. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA. 7. Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Boston, USA.
Abstract
PURPOSE: To understand trends in the incidence and mortality of two human papillomavirus (HPV)-associated cancers, cervical and oropharyngeal cancer, in Massachusetts. METHODS: From 2004 to 2014, the Massachusetts Cancer Registry recorded 3,996 incident cases of oropharyngeal cancer and 2,193 incident cases of cervical cancer. Mortality data were obtained from the Massachusetts Registry of Vital Records and Statistics from 2008 to 2014. Rates were age-standardized to the 2000 U.S. population and trends were assessed using joinpoint regression. RESULTS: While the incidence rate of cervical cancer (5.46 per 100,000) decreased by 2.41% annually (p = 0.004), the incidence rate of oropharyngeal cancer among males (7.85 per 100,000) increased by 2.82% annually (p = 0.0002). Mortality rates for both cancers decreased from 2008 to 2014 but were not statistically significant (cervical - 3.73% annually, p = 0.29; oropharyngeal - 1.94% annually, p = 0.44). CONCLUSION: The rising incidence rate of oropharyngeal cancer in men and the decreasing, but relatively high, incidence rate of cervical cancer in women highlight the need for further screening and prevention by HPV vaccination in Massachusetts.
PURPOSE: To understand trends in the incidence and mortality of two human papillomavirus (HPV)-associated cancers, cervical and oropharyngeal cancer, in Massachusetts. METHODS: From 2004 to 2014, the Massachusetts Cancer Registry recorded 3,996 incident cases of oropharyngeal cancer and 2,193 incident cases of cervical cancer. Mortality data were obtained from the Massachusetts Registry of Vital Records and Statistics from 2008 to 2014. Rates were age-standardized to the 2000 U.S. population and trends were assessed using joinpoint regression. RESULTS: While the incidence rate of cervical cancer (5.46 per 100,000) decreased by 2.41% annually (p = 0.004), the incidence rate of oropharyngeal cancer among males (7.85 per 100,000) increased by 2.82% annually (p = 0.0002). Mortality rates for both cancers decreased from 2008 to 2014 but were not statistically significant (cervical - 3.73% annually, p = 0.29; oropharyngeal - 1.94% annually, p = 0.44). CONCLUSION: The rising incidence rate of oropharyngeal cancer in men and the decreasing, but relatively high, incidence rate of cervical cancer in women highlight the need for further screening and prevention by HPV vaccination in Massachusetts.
Entities:
Keywords:
Cancer; Cervical cancer; Human papillomavirus (HPV); Massachusetts; Oropharyngeal cancer; Population Surveillance
Authors: Mona Saraiya; Elizabeth R Unger; Trevor D Thompson; Charles F Lynch; Brenda Y Hernandez; Christopher W Lyu; Martin Steinau; Meg Watson; Edward J Wilkinson; Claudia Hopenhayn; Glenn Copeland; Wendy Cozen; Edward S Peters; Youjie Huang; Maria Sibug Saber; Sean Altekruse; Marc T Goodman Journal: J Natl Cancer Inst Date: 2015-04-29 Impact factor: 13.506
Authors: Anil K Chaturvedi; Eric A Engels; Ruth M Pfeiffer; Brenda Y Hernandez; Weihong Xiao; Esther Kim; Bo Jiang; Marc T Goodman; Maria Sibug-Saber; Wendy Cozen; Lihua Liu; Charles F Lynch; Nicolas Wentzensen; Richard C Jordan; Sean Altekruse; William F Anderson; Philip S Rosenberg; Maura L Gillison Journal: J Clin Oncol Date: 2011-10-03 Impact factor: 44.544
Authors: Anthony C Nichols; Dianne M Finkelstein; William C Faquin; William H Westra; Edmund A Mroz; Peter Kneuertz; Shahnaz Begum; William A Michaud; Paul M Busse; John R Clark; James W Rocco Journal: Clin Cancer Res Date: 2010-03-16 Impact factor: 12.531
Authors: Elin Ringström; Edward Peters; Masayuki Hasegawa; Marshall Posner; Mei Liu; Karl T Kelsey Journal: Clin Cancer Res Date: 2002-10 Impact factor: 12.531
Authors: Eileen F Dunne; Elizabeth R Unger; Maya Sternberg; Geraldine McQuillan; David C Swan; Sonya S Patel; Lauri E Markowitz Journal: JAMA Date: 2007-02-28 Impact factor: 56.272
Authors: Laura J Viens; S Jane Henley; Meg Watson; Lauri E Markowitz; Cheryll C Thomas; Trevor D Thompson; Hilda Razzaghi; Mona Saraiya Journal: MMWR Morb Mortal Wkly Rep Date: 2016-07-08 Impact factor: 17.586
Authors: Heather H Nelson; Michael Pawlita; Dominique S Michaud; Michael McClean; Scott M Langevin; Melissa N Eliot; Karl T Kelsey Journal: JAMA Oncol Date: 2017-02-01 Impact factor: 31.777
Authors: Daniel Addison; Sara B Seidelmann; Sumbal A Janjua; Hamed Emami; Pedro V Staziaki; Travis R Hallett; Bálint Szilveszter; Michael T Lu; Richard P Cambria; Udo Hoffmann; Annie W Chan; Lori J Wirth; Tomas G Neilan Journal: J Am Heart Assoc Date: 2017-08-30 Impact factor: 5.501
Authors: Eleonore B Baughan; Erin M Keizur; Christopher A Damico; Elizabeth Mayfield Arnold; Jamie S Ko; Jeffrey D Klausner Journal: Sex Transm Dis Date: 2019-08 Impact factor: 2.830