Literature DB >> 29496957

Quantitative analysis of population-scale family trees with millions of relatives.

Joanna Kaplanis1,2, Assaf Gordon1,2, Tal Shor3,4, Omer Weissbrod5, Dan Geiger4, Mary Wahl1,2,6, Michael Gershovits2, Barak Markus2, Mona Sheikh2, Melissa Gymrek1,2,7,8,9, Gaurav Bhatia10,11, Daniel G MacArthur7,9,10, Alkes L Price10,11,12, Yaniv Erlich13,2,3,14,15.   

Abstract

Family trees have vast applications in fields as diverse as genetics, anthropology, and economics. However, the collection of extended family trees is tedious and usually relies on resources with limited geographical scope and complex data usage restrictions. We collected 86 million profiles from publicly available online data shared by genealogy enthusiasts. After extensive cleaning and validation, we obtained population-scale family trees, including a single pedigree of 13 million individuals. We leveraged the data to partition the genetic architecture of human longevity and to provide insights into the geographical dispersion of families. We also report a simple digital procedure to overlay other data sets with our resource.
Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Year:  2018        PMID: 29496957      PMCID: PMC6593158          DOI: 10.1126/science.aam9309

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  43 in total

1.  Crowdsourced genealogies and genomes.

Authors:  Alexandre A Lussier; Alon Keinan
Journal:  Science       Date:  2018-04-13       Impact factor: 47.728

Review 2.  Genetic and epigenetic regulation of human aging and longevity.

Authors:  Brian J Morris; Bradley J Willcox; Timothy A Donlon
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2018-09-01       Impact factor: 5.187

3.  Electronically ascertained extended pedigrees in breast cancer genetic counseling.

Authors:  V Stefansdottir; H Skirton; O Th Johannsson; H Olafsdottir; G H Olafsdottir; L Tryggvadottir; J J Jonsson
Journal:  Fam Cancer       Date:  2019-04       Impact factor: 2.375

Review 4.  The genetics of human ageing.

Authors:  David Melzer; Luke C Pilling; Luigi Ferrucci
Journal:  Nat Rev Genet       Date:  2019-11-05       Impact factor: 53.242

5.  Human genetics: Population-scale family trees from publicly available data.

Authors:  Grant Otto
Journal:  Nat Rev Genet       Date:  2018-03-26       Impact factor: 53.242

6.  Inferring Transmission Histories of Rare Alleles in Population-Scale Genealogies.

Authors:  Dominic Nelson; Claudia Moreau; Marianne de Vriendt; Yixiao Zeng; Christoph Preuss; Hélène Vézina; Emmanuel Milot; Gregor Andelfinger; Damian Labuda; Simon Gravel
Journal:  Am J Hum Genet       Date:  2018-12-06       Impact factor: 11.025

Review 7.  Using Sox2 to alleviate the hallmarks of age-related hearing loss.

Authors:  Ebenezer N Yamoah; Mark Li; Anit Shah; Karen L Elliott; Kathy Cheah; Pin-Xian Xu; Stacia Phillips; Samuel M Young; Daniel F Eberl; Bernd Fritzsch
Journal:  Ageing Res Rev       Date:  2020-03-12       Impact factor: 10.895

8.  Perspective: Methionine Restriction-Induced Longevity-A Possible Role for Inhibiting the Synthesis of Bacterial Quorum Sensing Molecules.

Authors:  Peng Bin; Congrui Zhu; Shaojuan Liu; Zhendong Li; Wenkai Ren; Guoqiang Zhu
Journal:  Adv Nutr       Date:  2020-07-01       Impact factor: 8.701

Review 9.  Genomic and Phenomic Research in the 21st Century.

Authors:  Scott Hebbring
Journal:  Trends Genet       Date:  2018-10-17       Impact factor: 11.639

10.  Cohort Differences in the Associations of Selected Candidate Genes With Risk of All-Cause Mortality at Advanced Ages.

Authors:  Qihua Tan; Rune Jacobsen; Marianne Nygaard; Mette Soerensen; Jonas Mengel-From; Lene Christiansen; Kaare Christensen
Journal:  Am J Epidemiol       Date:  2020-07-01       Impact factor: 4.897

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