Dalila Lebsir1, Line Manens1, Stephane Grison1, Philippe Lestaevel1, Teni Ebrahimian1, David Suhard2, Guillaume Phan2, Isabelle Dublineau3, Karine Tack1, Marc Benderitter3, Annick Pech4, Jean-Rene Jourdain3, Maâmar Souidi5. 1. Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, 92262 Fontenay-aux-Roses, France. 2. Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM, SDI, LRC, 92262 Fontenay-aux-Roses, France. 3. Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM, 92262 Fontenay-aux-Roses, France. 4. Pharmacie centrale des armées, Direction des Approvisionnement en produits de Santé des Armées, 45000 Orléans, France. 5. Institut de Radioprotection et de Sûreté Nucléaire (IRSN), PRP-HOM, SRBE, LRTOX, 92262 Fontenay-aux-Roses, France. Electronic address: maamar.souidi@irsn.fr.
Abstract
BACKGROUND: A single dose of potassium iodide (KI) is recommended to reduce the risk of thyroid cancer during nuclear accidents. However in case of prolonged radioiodine exposure, more than one dose of KI may be necessary. This work aims to evaluate the potential toxic effect of repeated administration of KI. METHODS: Adult Wistar rats received an optimal dose of KI 1 mg/kg over a period of 1, 4 or 8 days. RESULTS: hormonal status (TSH, FT4) of treated rats was unaffected. Contrariwise, a sequential Wolff-Chaikoff effect was observed, resulting in a prompt decrease of NIS and MCT8 mRNA expression (-58% and -26% respectively), followed by a delayed decrease of TPO mRNA expression (-33%) in conjunction with a stimulation of PDS mRNA expression (+62%). CONCLUSION: we show for the first time that repeated administration of KI at 1 mg/kg/24h doesn't cause modification of thyroid hormones level, but leads to a reversible modification of the expression of genes involved in the synthesis and secretion of thyroid hormones.
BACKGROUND: A single dose of potassium iodide (KI) is recommended to reduce the risk of thyroid cancer during nuclear accidents. However in case of prolonged radioiodine exposure, more than one dose of KI may be necessary. This work aims to evaluate the potential toxic effect of repeated administration of KI. METHODS: Adult Wistar rats received an optimal dose of KI 1 mg/kg over a period of 1, 4 or 8 days. RESULTS: hormonal status (TSH, FT4) of treated rats was unaffected. Contrariwise, a sequential Wolff-Chaikoff effect was observed, resulting in a prompt decrease of NIS and MCT8 mRNA expression (-58% and -26% respectively), followed by a delayed decrease of TPO mRNA expression (-33%) in conjunction with a stimulation of PDS mRNA expression (+62%). CONCLUSION: we show for the first time that repeated administration of KI at 1 mg/kg/24h doesn't cause modification of thyroid hormones level, but leads to a reversible modification of the expression of genes involved in the synthesis and secretion of thyroid hormones.
Authors: Y Nishikawa; C Suzuki; Y Takahashi; T Sawano; H Kinoshita; E Clero; D Laurier; G Phan; T Nakayama; M Tsubokura Journal: J Endocrinol Invest Date: 2020-11-18 Impact factor: 4.256