Corrine Hanson1, Elizabeth Lyden2, Jeremy Furtado3, Matthew Van Ormer4, Marina Schumacher5, Ammar Kamil6, Elizabeth McGinn6, Katherine Rilett6, Elizabeth Elliott6, Caleb Cave6, Rebecca Johnson6, Kara Weishaar6, Ann Anderson-Berry7. 1. University of Nebraska Medical Center, College of Allied Health Professions, Medical Nutrition Education, 984045 Nebraska Medical Center, Omaha, NE 68198-4045, USA. Electronic address: ckhanson@unmc.edu. 2. University of Nebraska Medical Center, College of Public Health, 984375 Nebraska Medical Center, Omaha, NE 68198-4375, USA. Electronic address: elyden@unmc.edu. 3. Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02215, USA. Electronic address: jfurtado@hsph.harvard.edu. 4. University of Nebraska Medical Center, Department of Pediatrics, 981205 Nebraska Medical Center, Omaha, NE 68198-1205, USA. Electronic address: Matthew.vanormer@unmc.edu. 5. University of Nebraska Medical Center, College of Allied Health Professions, Medical Nutrition Education, 984045 Nebraska Medical Center, Omaha, NE 68198-4045, USA. 6. University of Nebraska Medical Center, Department of Pediatrics, 981205 Nebraska Medical Center, Omaha, NE 68198-1205, USA. 7. University of Nebraska Medical Center, Department of Pediatrics, 981205 Nebraska Medical Center, Omaha, NE 68198-1205, USA. Electronic address: alanders@unmc.edu.
Abstract
BACKGROUND: Oxidative stress has been associated with adverse neonatal outcomes, and vitamin E has powerful anti-oxidant properties. Vitamin E occurs in several different isoforms which differ in their ability to modulate inflammation and oxidative stress. Therefore, the purpose of this study was to evaluate the status of α-, γ- and δ-tocopherol in maternal-infant pairs, and the impact on maternal-newborn outcomes. METHODS: Vitamin E status was evaluated in 189 mother-infant pairs. Concentrations of α-, γ- and δ-tocopherol were measured using HPLC. Descriptive statistics were calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements. Linear and logistic regression models were used to adjust for relevant confounders. A p < 0.05 was considered statistically significant. RESULTS: Maternal and cord serum tocopherol concentrations were positively correlated for γ-tocopherol (r = 0.32, p ˂ 0.001) and δ-tocopherol (r = 0.46, p ˂ 0.001) but not for α-tocopherol. After adjustment for confounders, maternal concentrations of tocopherols were positively associated with Apgar scores (p = 0.02) and infant growth parameters at birth. Conversely, cord tocopherol levels were inversely associated with Apgar scores (p = 0.02) and infant growth. Cord concentrations of α-tocopherol were higher in infants born to mothers with a diagnosis of pre-eclampsia (p = 0.04). CONCLUSION: Maternal-fetal transfer of γ- and δ-tocopherols is higher than α-tocopherol and may be mediated by either different or more efficient methods, conversely tissue uptake of α-tocopherol by the developing fetus may be higher. As serum levels of maternal tocopherols are positively associated with outcomes while higher cord levels show a negative impact, uptake and tissue deposition of vitamin E by the fetus may be crucial in growth and development. More research into the role of maternal diet, placental regulation, and fetal uptake of vitamin E tocopherols in relation to clinical outcomes is warranted.
BACKGROUND: Oxidative stress has been associated with adverse neonatal outcomes, and vitamin E has powerful anti-oxidant properties. Vitamin E occurs in several different isoforms which differ in their ability to modulate inflammation and oxidative stress. Therefore, the purpose of this study was to evaluate the status of α-, γ- and δ-tocopherol in maternal-infant pairs, and the impact on maternal-newborn outcomes. METHODS:Vitamin E status was evaluated in 189 mother-infant pairs. Concentrations of α-, γ- and δ-tocopherol were measured using HPLC. Descriptive statistics were calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements. Linear and logistic regression models were used to adjust for relevant confounders. A p < 0.05 was considered statistically significant. RESULTS: Maternal and cord serum tocopherol concentrations were positively correlated for γ-tocopherol (r = 0.32, p ˂ 0.001) and δ-tocopherol (r = 0.46, p ˂ 0.001) but not for α-tocopherol. After adjustment for confounders, maternal concentrations of tocopherols were positively associated with Apgar scores (p = 0.02) and infant growth parameters at birth. Conversely, cord tocopherol levels were inversely associated with Apgar scores (p = 0.02) and infant growth. Cord concentrations of α-tocopherol were higher in infants born to mothers with a diagnosis of pre-eclampsia (p = 0.04). CONCLUSION: Maternal-fetal transfer of γ- and δ-tocopherols is higher than α-tocopherol and may be mediated by either different or more efficient methods, conversely tissue uptake of α-tocopherol by the developing fetus may be higher. As serum levels of maternal tocopherols are positively associated with outcomes while higher cord levels show a negative impact, uptake and tissue deposition of vitamin E by the fetus may be crucial in growth and development. More research into the role of maternal diet, placental regulation, and fetal uptake of vitamin E tocopherols in relation to clinical outcomes is warranted.
Authors: Melissa Thoene; Matthew Van Ormer; Ana Yuil-Valdes; Taylor Bruett; Sathish Kumar Natarajan; Maheswari Mukherjee; Maranda Thompson; Tara M Nordgren; Wendy Van Lippevelde; Nina C Overby; Kwame Adu-Bonsaffoh; Ann Anderson-Berry; Corrine Hanson Journal: Placenta Date: 2019-12-05 Impact factor: 3.481
Authors: Erica E D'Souza; Rutvi Vyas; Michaela Sisitsky; Henry A Feldman; Borjan Gagoski; Jonathan Litt; Ryan J Larsen; Matthew J Kuchan; John B Lasekan; Brad P Sutton; Patricia Ellen Grant; Yangming Ou; Sarah U Morton Journal: Nutrients Date: 2022-05-26 Impact factor: 6.706
Authors: Caleb Cave; Corrine Hanson; Marina Schumacher; Elizabeth Lyden; Jeremy Furtado; Stephen Obaro; Shirley Delair; Nicholas Kocmich; Amy Rezac; N I Izevbigie; Matthew Van Ormer; Ammar Kamil; Elizabeth McGinn; Katherine Rilett; Elizabeth Elliott; Rebecca Johnson; Kara Weishaar; E K Olateju; G A Akaba; E A Anigilaje; Tahiru Tahiru; Ann Anderson-Berry Journal: Nutrients Date: 2018-09-14 Impact factor: 5.717