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Literature DB >> 29496094

Clinical Trials and Progress in Metastatic Colon Cancer.

Abstract

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide but associated mortality has declined in recent decades. Genomic profiling of the disease has resulted in the definition of subsets of patients-for example, KRAS, NRAS, or BRAF mutated; Her2 amplified; and mismatch repair deficient-which has enabled personalization of therapeutic decision making. These subsets are guiding drug development and combination therapy approaches using both targeted therapies and immunotherapies. Further refinement based on molecular discoveries and the emergence of newer technologies to enable new discoveries allow for great optimism for the future on behalf of patients with colon cancer.

Entities: Disease Gene Species

Keywords: BRAF; Clinical trials; Colorectal cancer; Her2; Immunotherapy; KRAS

Mesh：

Year: 2018 PMID： 29496094 DOI： 10.1016/j.soc.2017.11.008

Source DB: PubMed Journal: Surg Oncol Clin N Am ISSN： 1055-3207 Impact factor: 3.495

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Cited

23 in total

1. Whole-body MRI compared with standard pathways for staging metastatic disease in lung and colorectal cancer: the Streamline diagnostic accuracy studies.

Authors: Stuart A Taylor; Susan Mallett; Anne Miles; Stephen Morris; Laura Quinn; Caroline S Clarke; Sandy Beare; John Bridgewater; Vicky Goh; Sam Janes; Dow-Mu Koh; Alison Morton; Neal Navani; Alfred Oliver; Anwar Padhani; Shonit Punwani; Andrea Rockall; Steve Halligan
Journal: Health Technol Assess Date: 2019-12 Impact factor: 4.014

2. Proteomic Profiling of Colon Cancer Tissues: Discovery of New Candidate Biomarkers.

Authors: Miriam Buttacavoli; Nadia Ninfa Albanese; Elena Roz; Ida Pucci-Minafra; Salvatore Feo; Patrizia Cancemi
Journal: Int J Mol Sci Date: 2020-04-28 Impact factor: 5.923

3. Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer: the prospective Streamline C trial.

Authors: Stuart A Taylor; Sue Mallett; Sandy Beare; Gauraang Bhatnagar; Dominic Blunt; Peter Boavida; John Bridgewater; Caroline S Clarke; Marian Duggan; Steve Ellis; Robert Glynne-Jones; Vicky Goh; Ashley M Groves; Ayshea Hameeduddin; Sam M Janes; Edward W Johnston; Dow-Mu Koh; Anne Miles; Stephen Morris; Alison Morton; Neal Navani; John O'Donohue; Alfred Oliver; Anwar R Padhani; Helen Pardoe; Uday Patel; Shonit Punwani; Laura Quinn; Hameed Rafiee; Krystyna Reczko; Andrea G Rockall; Khawaja Shahabuddin; Harbir S Sidhu; Jonathan Teague; Mohamed A Thaha; Matthew Train; Katherine van Ree; Sanjaya Wijeyekoon; Steve Halligan
Journal: Lancet Gastroenterol Hepatol Date: 2019-05-09

4. The clinical and prognostic evaluation of GRP94 immunoexpression in Caucasian patients with colorectal adenocarcinoma.

Authors: Marlena Brzozowa-Zasada; Józef Kurek; Adam Piecuch; Grzegorz Wyrobiec
Journal: Prz Gastroenterol Date: 2019-07-05

Review 5. Antitumor pharmacotherapy of colorectal cancer in kidney transplant recipients.

Authors: Yuanyuan Fu; Chengheng Liao; Kai Cui; Xiao Liu; Wentong Fang
Journal: Ther Adv Med Oncol Date: 2019-09-23 Impact factor: 8.168

6. IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer.

Authors: Lei Zhang; Wen Liu; Fangyan Liu; Qun Wang; Mengjiao Song; Qi Yu; Kun Tang; Tieshan Teng; Dongdong Wu; Xijing Wang; Wuqi Han; Yanzhang Li
Journal: Oxid Med Cell Longev Date: 2020-04-03 Impact factor: 6.543

7. Integrative analysis of ceRNA network reveals functional lncRNAs associated with independent recurrent prognosis in colon adenocarcinoma.

Authors: Yinling Mao; Jiachen Lv; Li Jiang; Yihui Wang
Journal: Cancer Cell Int Date: 2021-07-05 Impact factor: 5.722