Literature DB >> 29492872

Intestinal microbiota and the immune system in metabolic diseases.

Panida Sittipo1, Stefani Lobionda1, Yun Kyung Lee2, Craig L Maynard3.   

Abstract

The intestinal microbiota is comprised of millions of microorganisms that reside in the gastrointestinal tract and consistently interact with the host. Host factors such as diet and disease status affect the composition of the microbiota, while the microbiota itself produces metabolites that can further manipulate host physiology. Dysbiosis of the intestinal microbiota has been characterized in patients with certain metabolic diseases, some of which involve damage to the host intestinal epithelial barrier and alterations in the immune system. In this review, we will discuss the consequences of dietdependent bacterial dysbiosis in the gastrointestinal tract, and how the associated interaction with epithelial and immune cells impacts metabolic diseases.

Entities:  

Keywords:  dysbiosis; immune system; intestinal barrier; intestinal microbiota; metabolic disease

Mesh：

Year:  2018        PMID： 29492872     DOI： 10.1007/s12275-018-7548-y

Source DB:  PubMed          Journal:  J Microbiol        ISSN： 1225-8873            Impact factor:   3.422


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