Angiolo Gadducci1, Maria Elena Guerrieri2, Stefania Cosio2, Maria Grazia Fabrini3, Concetta Laliscia3, Daniela Attianese4, Annalisa Rossi5, Annamaria Ferrero4. 1. Department of Experimental and Clinical Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy a.gadducci@med.unipi.it. 2. Department of Experimental and Clinical Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy. 3. Department of Oncology, Division of Radiation Oncology, University of Pisa, Pisa, Italy. 4. Academic Department of Gynecology and Obstetrics, University of Torino, Mauriziano Hospital, Turin, Italy. 5. Division of Radiation Therapy, Mauriziano Hospital, Turin, Italy.
Abstract
BACKGROUND/AIM: To assess the patterns of recurrence of node-positive endometrial cancer patients. PATIENTS AND METHODS: This investigation assessed 82 patients who received different postoperative treatments. RESULTS: Recurrence developed in 36 patients after a median time of 13.5 months, and involved the vagina, pelvic nodes, para-aortic nodes and distant sites in 5, 8, 16 and 17 patients, respectively. Five-year progression-free survival (PFS) and 5-year overall survival (OS) were 51.1% and 59.8%. PFS and OS were significantly better for endometrioid than for non-endometrioid tumors. There was a trend towards a better outcome for patients who underwent chemotherapy±radiotherapy compared to those who received radiotherapy alone. Among the former, there was a better 5-year PFS (65.8% versus 33.7%, p=0.038) in patients who received platinum/paclitaxel-based regimens compared to those who received platinum-based chemotherapy. CONCLUSION: Disease recurred in 43.9% of patients, and platinum/paclitaxel-based chemotherapy plus radiotherapy appeared to be the best adjuvant treatment. Copyright
BACKGROUND/AIM: To assess the patterns of recurrence of node-positive endometrial cancerpatients. PATIENTS AND METHODS: This investigation assessed 82 patients who received different postoperative treatments. RESULTS: Recurrence developed in 36 patients after a median time of 13.5 months, and involved the vagina, pelvic nodes, para-aortic nodes and distant sites in 5, 8, 16 and 17 patients, respectively. Five-year progression-free survival (PFS) and 5-year overall survival (OS) were 51.1% and 59.8%. PFS and OS were significantly better for endometrioid than for non-endometrioid tumors. There was a trend towards a better outcome for patients who underwent chemotherapy±radiotherapy compared to those who received radiotherapy alone. Among the former, there was a better 5-year PFS (65.8% versus 33.7%, p=0.038) in patients who received platinum/paclitaxel-based regimens compared to those who received platinum-based chemotherapy. CONCLUSION: Disease recurred in 43.9% of patients, and platinum/paclitaxel-based chemotherapy plus radiotherapy appeared to be the best adjuvant treatment. Copyright
Authors: Alessia Aloisi; João Miguel Casanova; Jill H Tseng; Kristina A Seader; Nancy Thi Nguyen; Kaled M Alektiar; Vicky Makker; Sarah Chiang; Robert A Soslow; Mario M Leitao; Nadeem R Abu-Rustum Journal: Gynecol Oncol Date: 2018-10-02 Impact factor: 5.482