Yoshinaga Okugawa1,2,3, Yumiko Shirai4, Yuji Toiyama5, Susumu Saigusa3, Asahi Hishida6, Takeshi Yokoe3, Koji Tanaka3, Motoyoshi Tanaka2, Hiromi Yasuda5, Hiroyuki Fujikawa5, Junichiro Hiro5, Minako Kobayashi5, Toshimitsu Araki5, Yasuhiro Inoue5, Donald C McMillan7, Masato Kusunoki5, Chikao Miki8. 1. Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan yoshinaga.okugawa@gmail.com harborne3030@gmail.com. 2. Department of Medical oncology, Iga General City Hospital, Mie, Japan. 3. Department of Surgery, Iga General City Hospital, Mie, Japan. 4. Department of Nutrition, Iga General City Hospital, Mie, Japan. 5. Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan. 6. Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan. 7. Academic Unit of Surgery, School of Medicine, University of Glasgow, Glasgow Royal Infirmary, Glasgow, U.K. 8. Department of Surgery, Iga General City Hospital, Mie, Japan yoshinaga.okugawa@gmail.com harborne3030@gmail.com.
Abstract
BACKGROUND/AIM: This study aimed to clarify the potential of modified Glasgow Prognostic Score (mGPS) as a prognostic biomarker and reveal the significance of fish oil (FO)-enriched nutrition in colorectal cancer (CRC). PATIENTS AND METHODS: A total of 738 CRC patients from three different patient cohorts, including 670 patients in the biomarker study and 68 patients in the nutrition-intervention study, were analyzed. RESULTS: High preoperative mGPS was significantly correlated with well-recognized disease progression factors and advanced UICC stage classification. In addition, high mGPS was an independent prognostic factor in both cohorts, especially in stage III and IV patients. These statuses were maintained in postoperative course and correlated with sarcopenia. Furthermore, FO-enriched nutrition suppressed systemic inflammatory reaction and improved skeletal muscle mass and prognosis, especially in CRC patients with mGPS 1 or 2. CONCLUSION: Assessment of mGPS could identify patients with high-risk CRC, who might be candidates for FO-enriched nutrition. Copyright
BACKGROUND/AIM: This study aimed to clarify the potential of modified Glasgow Prognostic Score (mGPS) as a prognostic biomarker and reveal the significance of fish oil (FO)-enriched nutrition in colorectal cancer (CRC). PATIENTS AND METHODS: A total of 738 CRC patients from three different patient cohorts, including 670 patients in the biomarker study and 68 patients in the nutrition-intervention study, were analyzed. RESULTS: High preoperative mGPS was significantly correlated with well-recognized disease progression factors and advanced UICC stage classification. In addition, high mGPS was an independent prognostic factor in both cohorts, especially in stage III and IV patients. These statuses were maintained in postoperative course and correlated with sarcopenia. Furthermore, FO-enriched nutrition suppressed systemic inflammatory reaction and improved skeletal muscle mass and prognosis, especially in CRC patients with mGPS 1 or 2. CONCLUSION: Assessment of mGPS could identify patients with high-risk CRC, who might be candidates for FO-enriched nutrition. Copyright