Vaclav Vetvicka1, Jana Vetvickova2. 1. Department of Pathology, University of Louisville, Louisville, KY, U.S.A. Vaclav.vetvicka@louisville.edu. 2. Department of Pathology, University of Louisville, Louisville, KY, U.S.A.
Abstract
BACKGROUND/AIM: β-Glucans are well-established immunomodulators with strong effects across all immune reactions. Due to the extensive amount of studies, glucans are steadily progressing from a non-specific immunomodulator to a licensed drug. However, direct comparisons of higher numbers of different glucans are rare. MATERIALS AND METHODS: In this study, we used 16 different glucans isolated from yeasts, mushroom, algae, and oat and compared their effects on phagocytosis, IL-2 production, antibody secretion, and inhibition of three experimental cancer models. RESULTS: Our results showed significant differences among tested glucans, showing that despite the fact that glucans in general have strong stimulating effects on most aspects of the immune system, it is necessary to choose the right glucan. CONCLUSION: Based on our studies, we can conclude that highly purified and active glucans have significant pleiotropic effects. Copyright
BACKGROUND/AIM: β-Glucans are well-established immunomodulators with strong effects across all immune reactions. Due to the extensive amount of studies, glucans are steadily progressing from a non-specific immunomodulator to a licensed drug. However, direct comparisons of higher numbers of different glucans are rare. MATERIALS AND METHODS: In this study, we used 16 different glucans isolated from yeasts, mushroom, algae, and oat and compared their effects on phagocytosis, IL-2 production, antibody secretion, and inhibition of three experimental cancer models. RESULTS: Our results showed significant differences among tested glucans, showing that despite the fact that glucans in general have strong stimulating effects on most aspects of the immune system, it is necessary to choose the right glucan. CONCLUSION: Based on our studies, we can conclude that highly purified and active glucans have significant pleiotropic effects. Copyright