Literature DB >> 29489959

Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease.

Hossein Haddadi1, Ziba Rajaei1, Hojjatallah Alaei1, Somayeh Shahidani1.   

Abstract

The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25, 50 and 100 mg/kg, ip) for six weeks after surgery. The 6-OHDA-lesioned rats showed contralateral rotations towards the lesion side, which was accompanied by learning and memory deficits in a passive avoidance test and a decrease in tail withdrawal latency in a tail flick test at the end of week 6. The results also showed that treatment with carvacrol at a dose of 25 mg/kg ameliorated memory deficits, with no effect on rotations and hyperalgesia in lesioned rats. In conclusion, carvacrol improves memory impairments in rats with Parkinson's disease; therefore, it may serve as an adjunct therapy for the alleviation of memory deficits in Parkinson's disease patients.

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Year:  2018        PMID： 29489959     DOI： 10.1590/0004-282X20170193

Source DB:  PubMed          Journal:  Arq Neuropsiquiatr        ISSN： 0004-282X            Impact factor:   1.420


  16 in total

1.  Carvacrol Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in In Vivo and In Vitro Models of Parkinson's Disease.

Authors:  Mahboubeh Manouchehrabadi; Mona Farhadi; Zahra Azizi; Anahita Torkaman-Boutorabi
Journal:  Neurotox Res       Date:  2019-07-30       Impact factor: 3.911

2.  Pretreatment with crocin along with treadmill exercise ameliorates motor and memory deficits in hemiparkinsonian rats by anti-inflammatory and antioxidant mechanisms.

Authors:  Somayeh Shahidani; Ziba Rajaei; Hojjatallah Alaei
Journal:  Metab Brain Dis       Date:  2019-01-16       Impact factor: 3.584

3.  Protective Effects of Carvacrol on Brain Tissue Inflammation and Oxidative Stress as well as Learning and Memory in Lipopolysaccharide-Challenged Rats.

Authors:  Zhara Hakimi; Hossein Salmani; Narges Marefati; Zohre Arab; Zahra Gholamnezhad; Farimah Beheshti; Mohammad Naser Shafei; Mahmoud Hosseini
Journal:  Neurotox Res       Date:  2019-12-06       Impact factor: 3.911

4.  Supplementation of Carvacrol Attenuates Hippocampal Tumor Necrosis Factor-Alpha Level, Oxidative Stress, and Learning and Memory Dysfunction in Lipopolysaccharide-Exposed Rats.

Authors:  Zahra Amooheydari; Ziba Rajaei; Hojjatallah Alaei; Nafiseh Esmaeil
Journal:  Adv Biomed Res       Date:  2022-04-29

5.  Neuroprotective and memory enhancing effects of Zataria multiflora in lipopolysaccharide-treated rats.

Authors:  Zohreh Arab; Mahmoud Hosseini; Narges Marefati; Farimah Beheshti; Akbar Anaeigoudari; Hamid Reza Sadeghnia; Mohammad Hossein Boskabady
Journal:  Vet Res Forum       Date:  2022-03-15       Impact factor: 0.950

6.  Effect of Exhaustive Training or Forced Immobilization on Physiological Condition and Main Metabolic and Stress Markers of Wistar Male Rats.

Authors:  Yu S Sidorova; N A Petrov; S N Zorin; V K Mazo
Journal:  Bull Exp Biol Med       Date:  2021-07-23       Impact factor: 0.804

7.  Effects of Boswellia serrata resin extract on motor dysfunction and brain oxidative stress in an experimental model of Parkinson's disease.

Authors:  Parvaneh Doaee; Ziba Rajaei; Mehrdad Roghani; Hojjatallah Alaei; Mohammad Kamalinejad
Journal:  Avicenna J Phytomed       Date:  2019 May-Jun

Review 8.  Role of Dietary Supplements in the Management of Parkinson's Disease.

Authors:  Michele Ciulla; Lisa Marinelli; Ivana Cacciatore; Antonio Di Stefano
Journal:  Biomolecules       Date:  2019-07-10

9.  (-)-cis-Carveol, a Natural Compound, Improves β-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus.

Authors:  Lucian Hritcu; Razvan Stefan Boiangiu; Mayara Castro de Morais; Damião Pergentino de Sousa
Journal:  Biomed Res Int       Date:  2020-04-22       Impact factor: 3.411

10.  Schinus terebinthifolius Essential Oil Attenuates Scopolamine-Induced Memory Deficits via Cholinergic Modulation and Antioxidant Properties in a Zebrafish Model.

Authors:  Elena Todirascu-Ciornea; Heba A S El-Nashar; Nada M Mostafa; Omayma A Eldahshan; Razvan Stefan Boiangiu; Gabriela Dumitru; Lucian Hritcu; Abdel Nasser B Singab
Journal:  Evid Based Complement Alternat Med       Date:  2019-12-02       Impact factor: 2.629
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