Fatoumata Yanoga1, Ronald C Gentile1, Toco Y P Chui1, K Bailey Freund2,3,4,5, Millie Fell6, Rosa Dolz-Marco2,3, Richard B Rosen1. 1. Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York. 2. Vitreous Retina Macula Consultants of New York, New York. 3. LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, New York. 4. Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, New York. 5. Department of Ophthalmology, New York University School of Medicine, New York, New York. 6. Brighton Eye Associates, Brooklyn, New York.
Abstract
BACKGROUND/ PURPOSE: To report a case of persistent retinal toxicity associated with a high dose of sildenafil citrate intake. METHODS: Single retrospective case report. RESULTS: A 31-year-old white man with no medical history presented with complaints of bilateral multicolored photopsias and erythropsia (red-tinted vision), shortly after taking sildenafil citrate-purchased through the internet. Patient was found to have cone photoreceptor damage, demonstrated using electroretinogram, optical coherence tomography, and adaptive optics imaging. The patient's symptoms and the photoreceptor structural changes persisted for several months. CONCLUSION: Sildenafil citrate is a widely used erectile dysfunction medication that is typically associated with transient visual symptoms in normal dosage. At high dosage, sildenafil citrate can lead to persistent retinal toxicity in certain individuals.
BACKGROUND/ PURPOSE: To report a case of persistent retinal toxicity associated with a high dose of sildenafil citrate intake. METHODS: Single retrospective case report. RESULTS: A 31-year-old white man with no medical history presented with complaints of bilateral multicolored photopsias and erythropsia (red-tinted vision), shortly after taking sildenafil citrate-purchased through the internet. Patient was found to have cone photoreceptor damage, demonstrated using electroretinogram, optical coherence tomography, and adaptive optics imaging. The patient's symptoms and the photoreceptor structural changes persisted for several months. CONCLUSION:Sildenafil citrate is a widely used erectile dysfunction medication that is typically associated with transient visual symptoms in normal dosage. At high dosage, sildenafil citrate can lead to persistent retinal toxicity in certain individuals.
Authors: Lisa Nivison-Smith; Yuan Zhu; Andrew Whatham; Bang V Bui; Erica L Fletcher; Monica L Acosta; Michael Kalloniatis Journal: Exp Eye Res Date: 2014-09-17 Impact factor: 3.467
Authors: Herbert Jägle; Christine Jägle; Ludwig Sérey; Alice Yu; Albrecht Rilk; Bettina Sadowski; Dorothea Besch; Eberhart Zrenner; Lindsay T Sharpe Journal: Am J Ophthalmol Date: 2004-05 Impact factor: 5.258
Authors: D Jackson Coleman; Winston Lee; Suzanne Daly; Mark P Breazzano; Janet Sparrow; Stephen H Tsang Journal: Am J Ophthalmol Case Rep Date: 2020-12-03
Authors: Birthe Dorgau; Maria Georgiou; Alexander Chaudhary; Marina Moya-Molina; Joseph Collin; Rachel Queen; Gerrit Hilgen; Tracey Davey; Philip Hewitt; Michael Schmitt; Stefan Kustermann; Francois Pognan; David H Steel; Evelyne Sernagor; Lyle Armstrong; Majlinda Lako Journal: Stem Cells Transl Med Date: 2022-03-17 Impact factor: 7.655