Stephanie Nougaret1,2,3, Yulia Lakhman2, Nicolas Molinari4, Diana Feier2,5, Chiara Scelzo2,6, Hebert A Vargas2, Ramon E Sosa2, Hedvig Hricak2, Robert A Soslow7, Rachel N Grisham8, Evis Sala2. 1. 1 Service de Radiologie, Institut Régional du Cancer de Montpellier, 208 Avenue des Apothicaires, Montpellier, Herault 34298, France. 2. 2 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY. 3. 3 Institut de Recherche en Cancérologie de Montpellier, University of Montpellier, Montpellier, France. 4. 4 Department of Statistics, Centre Hospitalier Universitaire de Montpellier, University of Montpellier, Montpellier, France. 5. 5 Department of Radiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. 6. 6 Department of Surgery, Gynecology and Obstetrics Section, Tor Vergata University, Rome, Italy. 7. 7 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY. 8. 8 Department of Medicine, Gynecologic Medical Oncology Service, Weill Cornell Medical College, New York, NY.
Abstract
OBJECTIVE: The objective of our study was to investigate whether the CT features of serous borderline tumors (SBTs) differ from those of low-grade serous carcinomas (LGSCs) and to evaluate if mutation status is associated with distinct CT phenotypes. MATERIALS AND METHODS: This retrospective study included 59 women, 37 with SBT and 22 with LGSC, who underwent CT before primary surgical resection. Thirty of 59 patients were genetically profiled. Two radiologists (readers 1 and 2) independently and retrospectively reviewed CT examinations for qualitative features and quantified total tumor volumes (TTVs), solid tumor volumes (STVs), and solid proportion of ovarian masses. Univariate and multivariate associations of the CT features with histopathologic diagnoses and mutations were evaluated, and interreader agreement was determined. RESULTS: At multivariate analysis, the presence of bilateral ovarian masses (p = 0.03), the presence of peritoneal disease (PD) (p = 0.002), and higher STV of ovarian masses (p = 0.002) were associated with LGSC. The presence of nodular PD pattern (p < 0.001 each reader) and the presence of PD calcifications (reader 1, p = 0.02; reader 2, p = 0.003) were associated with invasive peritoneal lesions (i.e., LGSC). The presence of bilateral ovarian masses (p = 0.04 each reader), PD (reader 1, p = 0.01; reader 2, p = 0.004), and higher STV (p = 0.03 for each reader) were associated with the absence of BRAF mutation (i.e., wild type [wt]-BRAF). CONCLUSION: The CT features of LGSCs were distinct from those of SBTs. The CT manifestations of LGSC and the wt-BRAF phenotype were similar.
OBJECTIVE: The objective of our study was to investigate whether the CT features of serous borderline tumors (SBTs) differ from those of low-grade serous carcinomas (LGSCs) and to evaluate if mutation status is associated with distinct CT phenotypes. MATERIALS AND METHODS: This retrospective study included 59 women, 37 with SBT and 22 with LGSC, who underwent CT before primary surgical resection. Thirty of 59 patients were genetically profiled. Two radiologists (readers 1 and 2) independently and retrospectively reviewed CT examinations for qualitative features and quantified total tumor volumes (TTVs), solid tumor volumes (STVs), and solid proportion of ovarian masses. Univariate and multivariate associations of the CT features with histopathologic diagnoses and mutations were evaluated, and interreader agreement was determined. RESULTS: At multivariate analysis, the presence of bilateral ovarian masses (p = 0.03), the presence of peritoneal disease (PD) (p = 0.002), and higher STV of ovarian masses (p = 0.002) were associated with LGSC. The presence of nodular PD pattern (p < 0.001 each reader) and the presence of PD calcifications (reader 1, p = 0.02; reader 2, p = 0.003) were associated with invasive peritoneal lesions (i.e., LGSC). The presence of bilateral ovarian masses (p = 0.04 each reader), PD (reader 1, p = 0.01; reader 2, p = 0.004), and higher STV (p = 0.03 for each reader) were associated with the absence of BRAF mutation (i.e., wild type [wt]-BRAF). CONCLUSION: The CT features of LGSCs were distinct from those of SBTs. The CT manifestations of LGSC and the wt-BRAF phenotype were similar.
Authors: He An; Yiang Wang; Esther M F Wong; Shanshan Lyu; Lujun Han; Jose A U Perucho; Peng Cao; Elaine Y P Lee Journal: Eur Radiol Date: 2021-01-06 Impact factor: 5.315