Literature DB >> 29485148

Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles.

Isabel Abánades Lázaro1, Sandra Abánades Lázaro, Ross S Forgan.   

Abstract

Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.

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Year:  2018        PMID： 29485148     DOI： 10.1039/c7cc09739e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

1.  Subchronic toxicity of magnesium oxide nanoparticles to Bombyx mori silkworm.

Authors:  Lin Ma; Vivian Andoh; Zhongyuan Shen; Haiyan Liu; Long Li; Keping Chen
Journal:  RSC Adv       Date:  2022-06-10       Impact factor: 4.036

2.  ZIF-8 Degrades in Cell Media, Serum, and Some-But Not All-Common Laboratory Buffers.

Authors:  Michael A Luzuriaga; Candace E Benjamin; Michael W Gaertner; Hamilton Lee; Fabian C Herbert; Snipta Mallick; Jeremiah J Gassensmith
Journal:  Supramol Chem       Date:  2019-05-11       Impact factor: 1.688

3.  High-yield halide-assisted synthesis of metal-organic framework UiO-based nanocarriers.

Authors:  Manuel Ceballos; Manuela Cedrún-Morales; Manuel Rodríguez-Pérez; Samuel Funes-Hernando; José Manuel Vila-Fungueiriño; Giulia Zampini; Maria F Navarro Poupard; Ester Polo; Pablo Del Pino; Beatriz Pelaz
Journal:  Nanoscale       Date:  2022-05-16       Impact factor: 8.307

4.  Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells.

Authors:  Alixandra Wagner; Qian Liu; Olivia L Rose; Anna Eden; Aishwarya Vijay; Yon Rojanasakul; Cerasela Zoica Dinu
Journal:  Int J Nanomedicine       Date:  2019-09-17

5.  Mineralization of pH-Sensitive Doxorubicin Prodrug in ZIF-8 to Enable Targeted Delivery to Solid Tumors.

Authors:  Jiaqi Yan; Chang Liu; Qiwei Wu; Junnian Zhou; Xiaoyu Xu; Lirong Zhang; Dongqing Wang; Fan Yang; Hongbo Zhang
Journal:  Anal Chem       Date:  2020-07-27       Impact factor: 6.986

6.  Hybrid Nanoparticles for Haloperidol Encapsulation: Quid Est Optimum?

Authors:  Sergey K Filippov; Ramil R Khusnutdinov; Wali Inham; Chang Liu; Dmitry O Nikitin; Irina I Semina; Christopher J Garvey; Shamil F Nasibullin; Vitaliy V Khutoryanskiy; Hongbo Zhang; Rouslan I Moustafine
Journal:  Polymers (Basel)       Date:  2021-11-30       Impact factor: 4.329

7.  Impact of Sodium Dichloroacetate Alone and in Combination Therapies on Lung Tumor Growth and Metastasis.

Authors:  Aya Al-Azawi; Shahrazad Sulaiman; Kholoud Arafat; Javed Yasin; Abderrahim Nemmar; Samir Attoub
Journal:  Int J Mol Sci       Date:  2021-11-21       Impact factor: 5.923

8.  Highly selective fluorescent turn-on-off sensing of OH-, Al3+ and Fe3+ ions by tuning ESIPT in metal organic frameworks and mitochondria targeted bio-imaging.

Authors:  Soumya Bhowal; Arijit Ghosh
Journal:  RSC Adv       Date:  2021-08-16       Impact factor: 4.036

Review 9.  Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications.

Authors:  Tiziana Tataranni; Claudia Piccoli
Journal:  Oxid Med Cell Longev       Date:  2019-11-14       Impact factor: 6.543

10.  Multivariate Modulation of the Zr MOF UiO-66 for Defect-Controlled Combination Anticancer Drug Delivery.

Authors:  Isabel Abánades Lázaro; Connor J R Wells; Ross S Forgan
Journal:  Angew Chem Int Ed Engl       Date:  2020-02-04       Impact factor: 15.336
  10 in total

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