Literature DB >> 29484558

Targeting Inflammatory Vasculature by Extracellular Vesicles.

Sihan Wang1, Xinyue Dong1, Jin Gao1, Zhenjia Wang2.   

Abstract

Extracellular vesicles (EVs) are cell membrane-derived compartments that regulate physiology and pathology in the body. Naturally secreted EVs have been well studied in their biogenesis and have been exploited in targeted drug delivery. Due to the limitations on production of EVs, nitrogen cavitation has been utilized to efficiently generate EV-like drug delivery systems used in treating inflammatory disorders. In this short review, we will discuss the production and purification of EVs, and we will summarize what technologies are needed to improve their production for translation. We describe the drug-loading processes in EVs and their applications as drug delivery systems for inflammatory therapies, focusing on a new type of EVs made from neutrophil membrane using nitrogen cavitation.

Entities:  

Keywords:  drug delivery; extracellular vesicles; inflamed endothelium; neutrophils

Mesh：

Substances：

Year:  2018        PMID： 29484558      PMCID： PMC6288379          DOI： 10.1208/s12248-018-0200-2

Source DB:  PubMed          Journal:  AAPS J        ISSN： 1550-7416            Impact factor:   4.009


  61 in total

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5.  Cell membrane-formed nanovesicles for disease-targeted delivery.

Authors:  Jin Gao; Dafeng Chu; Zhenjia Wang
Journal:  J Control Release       Date:  2016-01-14       Impact factor: 9.776

Review 6.  Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies.

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Journal:  Nat Rev Drug Discov       Date:  2014-08-08       Impact factor: 84.694

7.  Size and dynamics of caveolae studied using nanoparticles in living endothelial cells.

Authors:  Zhenjia Wang; Chinnaswamy Tiruppathi; Richard D Minshall; Asrar B Malik
Journal:  ACS Nano       Date:  2009-12-22       Impact factor: 15.881

8.  Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing.

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Journal:  PeerJ       Date:  2013-11-05       Impact factor: 2.984

Review 9.  The vascular endothelium and human diseases.

Authors:  Peramaiyan Rajendran; Thamaraiselvan Rengarajan; Jayakumar Thangavel; Yutaka Nishigaki; Dhanapal Sakthisekaran; Gautam Sethi; Ikuo Nishigaki
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10.  Extracellular vesicle-mediated export of fungal RNA.

Authors:  Roberta Peres da Silva; Rosana Puccia; Marcio L Rodrigues; Débora L Oliveira; Luna S Joffe; Gabriele V César; Leonardo Nimrichter; Samuel Goldenberg; Lysangela R Alves
Journal:  Sci Rep       Date:  2015-01-14       Impact factor: 4.379
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  10 in total

1.  Neutrophil Membrane-Derived Nanovesicles Alleviate Inflammation To Protect Mouse Brain Injury from Ischemic Stroke.

Authors:  Xinyue Dong; Jin Gao; Can Yang Zhang; Christopher Hayworth; Marcos Frank; Zhenjia Wang
Journal:  ACS Nano       Date:  2019-01-28       Impact factor: 15.881

Review 2.  COVID-19 inflammation and implications in drug delivery.

Authors:  Makhloufi Zoulikha; Feifei Huang; Zhenfeng Wu; Wei He
Journal:  J Control Release       Date:  2022-04-27       Impact factor: 11.467

Review 3.  Generation, purification and engineering of extracellular vesicles and their biomedical applications.

Authors:  Jin Gao; Xinyue Dong; Zhenjia Wang
Journal:  Methods       Date:  2019-11-30       Impact factor: 3.608

4.  Molecular Dynamics Simulations Provide Insight into the Loading Efficiency of Proresolving Lipid Mediators Resolvin D1 and D2 in Cell Membrane-Derived Nanovesicles.

Authors:  Jeevan B Gc; Christopher T Szlenk; Jin Gao; Xinyue Dong; Zhenjia Wang; Senthil Natesan
Journal:  Mol Pharm       Date:  2020-05-19       Impact factor: 4.939

Review 5.  Recent advances in Extracellular Vesicles and their involvements in vasculitis.

Authors:  Nan Yang; Yin Zhao; Xiuhua Wu; Na Zhang; Haoming Song; Wei Wei; Ming-Lin Liu
Journal:  Free Radic Biol Med       Date:  2021-05-02       Impact factor: 8.101

Review 6.  The Functional Heterogeneity of Neutrophil-Derived Extracellular Vesicles Reflects the Status of the Parent Cell.

Authors:  Ferenc Kolonics; Viktória Szeifert; Csaba I Timár; Erzsébet Ligeti; Ákos M Lőrincz
Journal:  Cells       Date:  2020-12-18       Impact factor: 6.600

7.  Extracellular vesicles from dHL-60 cells as delivery vehicles for diverse therapeutics.

Authors:  Jun-Kyu Kim; Young-Jin Youn; Yu-Bin Lee; Sun-Hwa Kim; Dong-Keun Song; Minsang Shin; Hee Kyung Jin; Jae-Sung Bae; Sanjeeb Shrestha; Chang-Won Hong
Journal:  Sci Rep       Date:  2021-04-15       Impact factor: 4.379

8.  RGD-expressed bacterial membrane-derived nanovesicles enhance cancer therapy via multiple tumorous targeting.

Authors:  Jin Gao; Sihan Wang; Xinyue Dong; Zhenjia Wang
Journal:  Theranostics       Date:  2021-01-15       Impact factor: 11.556

9.  Human neutrophil membrane-derived nanovesicles as a drug delivery platform for improved therapy of infectious diseases.

Authors:  Jin Gao; Xinyue Dong; Yujie Su; Zhenjia Wang
Journal:  Acta Biomater       Date:  2021-01-18       Impact factor: 8.947

10.  Liposomal Formulations Enhance the Anti-Inflammatory Effect of Eicosapentaenoic Acid in HL60 Cells.

Authors:  Puneet Kaur; Jin Gao; Zhenjia Wang
Journal:  Pharmaceutics       Date:  2022-02-26       Impact factor: 6.321
  10 in total

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