Literature DB >> 2948416

A radioenzymatic assay for quinolinic acid.

A C Foster, E Okuno, D S Brougher, R Schwarcz.   

Abstract

A new and rapid method for the determination of the excitotoxic tryptophan metabolite quinolinic acid is based on its enzymatic conversion to nicotinic acid mononucleotide and, in a second step utilizing [3H]ATP, further to [3H] deamido-NAD. Specificity of the assay is assured by using a highly purified preparation of the specific quinolinic acid-catabolizing enzyme, quinolinic acid phosphoribosyltransferase, in the initial step. The limit of sensitivity was found to be 2.5 pmol of quinolinic acid, sufficient to conveniently determine quinolinic acid levels in small volumes of human urine and blood plasma.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 2948416     DOI： 10.1016/0003-2697(86)90595-6

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  5 in total

1.  3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims.

Authors:  R Schwarcz; E Okuno; R J White; E D Bird; W O Whetsell
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

2.  Study of receptor-mediated neurotoxins released by HIV-1-infected mononuclear phagocytes found in human brain.

Authors:  D Giulian; J Yu; X Li; D Tom; J Li; E Wendt; S N Lin; R Schwarcz; C Noonan
Journal:  J Neurosci       Date:  1996-05-15       Impact factor: 6.167

3.  The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes.

Authors:  D Giulian; E Wendt; K Vaca; C A Noonan
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

Review 4.  Quinolinic acid: an endogenous neurotoxin with multiple targets.

Authors:  Rafael Lugo-Huitrón; Perla Ugalde Muñiz; Benjamin Pineda; José Pedraza-Chaverrí; Camilo Ríos; Verónica Pérez-de la Cruz
Journal:  Oxid Med Cell Longev       Date:  2013-09-05       Impact factor: 6.543

Review 5.  Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis.

Authors:  Michael D Lovelace; Bianca Varney; Gayathri Sundaram; Nunzio F Franco; Mei Li Ng; Saparna Pai; Chai K Lim; Gilles J Guillemin; Bruce J Brew
Journal:  Front Immunol       Date:  2016-08-04       Impact factor: 7.561
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.