Literature DB >> 29482782

Regulation of epithelial to mesenchymal transition by BRCA1 in breast cancer.

Satheesh Kumar Sengodan1, Sreelatha K H1, Revathy Nadhan1, Priya Srinivas2.   

Abstract

Reports till its discovery has proven multiple facets of Breast Cancer type 1 susceptibility gene (BRCA1) from nucleus to cytoplasm; from DNA repair to drug resistance; from Homologous Recombination (HR) to Ubiquitination; from breast to brain; from cancer to HIV and many of the roles are still unexplored. One of the recent attractions of BRCA1 is its role in regulating breast cancer metastasis though the exact mechanism is poorly understood. In this review, we will discuss the molecular interactions between BRCA1 and the key molecules of Epithelial to Mesenchymal Transition (EMT) associated with metastasis, its associated drug resistance and the possible treatment strategy for BRCA1 mutated breast cancer.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  BRCA1; Breast cancer; Drug resistance; Metastasis; epithelial to mesenchymal transition

Mesh：

Substances：

Year:  2018        PMID： 29482782     DOI： 10.1016/j.critrevonc.2018.01.008

Source DB:  PubMed          Journal:  Crit Rev Oncol Hematol        ISSN： 1040-8428            Impact factor:   6.312


  8 in total

Review 1.  The Breast Cancer Protooncogenes HER2, BRCA1 and BRCA2 and Their Regulation by the iNOS/NOS2 Axis.

Authors:  Katie Lin; Stavroula Baritaki; Silvia Vivarelli; Luca Falzone; Aurora Scalisi; Massimo Libra; Benjamin Bonavida
Journal:  Antioxidants (Basel)       Date:  2022-06-17

Review 2.  Circulating Tumor Cells in Breast Cancer Patients: A Balancing Act between Stemness, EMT Features and DNA Damage Responses.

Authors:  Benedikt Heitmeir; Miriam Deniz; Wolfgang Janni; Brigitte Rack; Fabienne Schochter; Lisa Wiesmüller
Journal:  Cancers (Basel)       Date:  2022-02-16       Impact factor: 6.639

Review 3.  The attributes of plakins in cancer and disease: perspectives on ovarian cancer progression, chemoresistance and recurrence.

Authors:  Tamsin Wesley; Stuart Berzins; George Kannourakis; Nuzhat Ahmed
Journal:  Cell Commun Signal       Date:  2021-05-17       Impact factor: 5.712

Review 4.  BRCA1 and Metastasis: Outcome of Defective DNA Repair.

Authors:  Rehna Krishnan; Parasvi S Patel; Razqallah Hakem
Journal:  Cancers (Basel)       Date:  2021-12-27       Impact factor: 6.639

5.  UBE2T regulates epithelial-mesenchymal transition through the PI3K-AKT pathway and plays a carcinogenic role in ovarian cancer.

Authors:  Ping Cui; Hao Li; Can Wang; Yuan Liu; Mengjun Zhang; Yue Yin; Zhenxing Sun; Yiru Wang; Xiuwei Chen
Journal:  J Ovarian Res       Date:  2022-09-10       Impact factor: 5.506

6.  Sensitization of Carboplatinum- and Taxol-Resistant High-Grade Serous Ovarian Cancer Cells Carrying p53, BRCA1/2 Mutations by Emblica officinalis (Amla) via Multiple Targets.

Authors:  Alok De; Archana De; Ramratan Sharma; William Suo; Mukut Sharma
Journal:  J Cancer       Date:  2020-01-29       Impact factor: 4.207

7.  Epithelial/mesenchymal heterogeneity of high-grade serous ovarian carcinoma samples correlates with miRNA let-7 levels and predicts tumor growth and metastasis.

Authors:  Evgeny Chirshev; Nozomi Hojo; Antonella Bertucci; Linda Sanderman; Anthony Nguyen; Hanmin Wang; Tise Suzuki; Emmanuel Brito; Shannalee R Martinez; Christine Castañón; Saied Mirshahidi; Marcelo E Vazquez; Pamela Wat; Kerby C Oberg; Yevgeniya J Ioffe; Juli J Unternaehrer
Journal:  Mol Oncol       Date:  2020-08-21       Impact factor: 7.449

8.  Classification of High-Grade Serous Ovarian Carcinoma by Epithelial-to-Mesenchymal Transition Signature and Homologous Recombination Repair Genes.

Authors:  Min-Hwan Sohn; Se Ik Kim; Jong-Yeon Shin; Hee Seung Kim; Hyun Hoon Chung; Jae-Weon Kim; Maria Lee; Jeong-Sun Seo
Journal:  Genes (Basel)       Date:  2021-07-20       Impact factor: 4.096
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.