| Literature DB >> 29481551 |
Rui Lin1,2,3, Qiru Feng2,4, Peng Li2, Ping Zhou2, Ruiyu Wang2, Zhe Liu2, Zhiqiang Wang2, Xiangbing Qi2, Nan Tang2, Feng Shao2, Minmin Luo2,4.
Abstract
Immunosignal hybridization chain reaction (isHCR) combines antibody-antigen interactions with hybridization chain reaction (HCR) technology, which results in amplification of immunofluorescence signals by up to two to three orders of magnitude with low background. isHCR's highly modular and easily adaptable design enables the technique to be applied broadly, and we further optimized its use in multiplexed imaging and in state-of-the-art tissue expansion and clearing techniques.Mesh：
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Year: 2018 PMID： 29481551 DOI： 10.1038/nmeth.4611
Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547