Literature DB >> 29480897

Reversible conduction block in peripheral nerve using electrical waveforms.

Niloy Bhadra1,1, Tina L Vrabec2,2, Narendra Bhadra2,2, Kevin L Kilgore3,4,3,4.   

Abstract

INTRODUCTION: Electrical nerve block uses electrical waveforms to block action potential propagation. MATERIALS &
METHODS: Two key features that distinguish electrical nerve block from other nonelectrical means of nerve block: block occurs instantly, typically within 1 s; and block is fully and rapidly reversible (within seconds).
RESULTS: Approaches for achieving electrical nerve block are reviewed, including kilohertz frequency alternating current and charge-balanced polarizing current. We conclude with a discussion of the future directions of electrical nerve block.
CONCLUSION: Electrical nerve block is an emerging technique that has many significant advantages over other methods of nerve block. This field is still in its infancy, but a significant expansion in the clinical application of this technique is expected in the coming years.

Entities:  

Keywords:  action potential; direct current; electrical nerve block; kilohertz frequency; neuromodulation; neuroprosthesis

Year:  2017        PMID: 29480897      PMCID: PMC5811084          DOI: 10.2217/bem-2017-0004

Source DB:  PubMed          Journal:  Bioelectron Med (Lond)        ISSN: 2059-1500


  68 in total

1.  Counted cycles method to quantify the onset response in high-frequency peripheral nerve block.

Authors:  Emily L Foldes; D Ackermann; Niloy Bhadra; Kevin L Kilgore
Journal:  Conf Proc IEEE Eng Med Biol Soc       Date:  2009

2.  Electrical stimulation with Pt electrodes: II-estimation of maximum surface redox (theoretical non-gassing) limits.

Authors:  S B Brummer; M J Turner
Journal:  IEEE Trans Biomed Eng       Date:  1977-09       Impact factor: 4.538

3.  An asymmetric two electrode cuff for generation of unidirectionally propagated action potentials.

Authors:  J D Sweeney; J T Mortimer
Journal:  IEEE Trans Biomed Eng       Date:  1986-06       Impact factor: 4.538

4.  Dynamics and sensitivity analysis of high-frequency conduction block.

Authors:  D Michael Ackermann; Niloy Bhadra; Meana Gerges; Peter J Thomas
Journal:  J Neural Eng       Date:  2011-11-04       Impact factor: 5.379

5.  Manipulation of muscle force with various firing rate and recruitment control strategies.

Authors:  B H Zhou; R Baratta; M Solomonow
Journal:  IEEE Trans Biomed Eng       Date:  1987-02       Impact factor: 4.538

6.  Response of single alpha motoneurons to high-frequency pulse trains. Firing behavior and conduction block phenomenon.

Authors:  B R Bowman; D R McNeal
Journal:  Appl Neurophysiol       Date:  1986

7.  Characterization of high capacitance electrodes for the application of direct current electrical nerve block.

Authors:  Tina Vrabec; Niloy Bhadra; Jesse Wainright; Narendra Bhadra; Manfred Franke; Kevin Kilgore
Journal:  Med Biol Eng Comput       Date:  2015-09-11       Impact factor: 2.602

8.  Modulation of motoneuronal firing behavior after spinal cord injury using intraspinal microstimulation current pulses: a modeling study.

Authors:  Sherif M Elbasiouny; Vivian K Mushahwar
Journal:  J Appl Physiol (1985)       Date:  2007-01-18

9.  Direct current contamination of kilohertz frequency alternating current waveforms.

Authors:  Manfred Franke; Niloy Bhadra; Narendra Bhadra; Kevin Kilgore
Journal:  J Neurosci Methods       Date:  2014-05-10       Impact factor: 2.390

Review 10.  Reversible nerve conduction block using kilohertz frequency alternating current.

Authors:  Kevin L Kilgore; Niloy Bhadra
Journal:  Neuromodulation       Date:  2013-08-07
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  6 in total

1.  Identifying the Role of Block Length in Neural Heat Block to Reduce Temperatures During Infrared Neural Inhibition.

Authors:  Jeremy B Ford; Mohit Ganguly; Megan E Poorman; William A Grissom; Michael W Jenkins; Hillel J Chiel; E Duco Jansen
Journal:  Lasers Surg Med       Date:  2019-07-25       Impact factor: 4.025

2.  Fuzzy Logic Control of Heartrate by Electrical Block of Vagus Nerve.

Authors:  Shane A Bender; David B Green; Robert J Daniels; Kevin L Kilgore; Niloy Bhadra; Tina L Vrabec
Journal:  Int IEEE EMBS Conf Neural Eng       Date:  2021-06-02

3.  HFAC Dose Repetition and Accumulation Leads to Progressively Longer Block Carryover Effect in Rat Sciatic Nerve.

Authors:  Adrien Rapeaux; Timothy G Constandinou
Journal:  Front Neurosci       Date:  2022-05-27       Impact factor: 5.152

4.  Transcutaneous electrical nerve inhibition using medium frequency alternating current.

Authors:  Seppe Maris; Michiel Brands; Daniele Lenskens; Geert Braeken; Stefan Kemnitz; Herbert Vanhove; Myles Mc Laughlin; Raf Meesen; Bert Brône; Björn Stessel
Journal:  Sci Rep       Date:  2022-09-01       Impact factor: 4.996

5.  Quantitative comparisons of block thresholds and onset responses for charge-balanced kilohertz frequency waveforms.

Authors:  Edgar Peña; Nicole A Pelot; Warren M Grill
Journal:  J Neural Eng       Date:  2020-09-18       Impact factor: 5.379

6.  Kilohertz waveforms optimized to produce closed-state Na+ channel inactivation eliminate onset response in nerve conduction block.

Authors:  Guosheng Yi; Warren M Grill
Journal:  PLoS Comput Biol       Date:  2020-06-15       Impact factor: 4.475

  6 in total

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