| Literature DB >> 29478267 |
Dandan Xu1, Michael J Daniels2, Almut G Winterstein3.
Abstract
We propose a Bayesian nonparametric approach (BNP) for causal inference on quantiles in the presence of many confounders. In particular, we define relevant causal quantities and specify BNP models to avoid bias from restrictive parametric assumptions. We first use Bayesian additive regression trees (BART) to model the propensity score and then construct the distribution of potential outcomes given the propensity score using a Dirichlet process mixture (DPM) of normals model. We thoroughly evaluate the operating characteristics of our approach and compare it to Bayesian and frequentist competitors. We use our approach to answer an important clinical question involving acute kidney injury using electronic health records.Entities:
Keywords: Bayesian additive regression trees (BART); Bayesian nonparametrics; Comparative effectiveness research; Dirichlet process mixture models; Propensity scores; Quantile causal effects
Mesh:
Year: 2018 PMID: 29478267 DOI: 10.1111/biom.12863
Source DB: PubMed Journal: Biometrics ISSN: 0006-341X Impact factor: 2.571