Literature DB >> 29478229

Pregnancy Alters Renal and Blood Burden of Mercury in Females.

Sarah E Orr1, Reneé C Franklin1, Hannah S George1, Sanya Nijhara1, Lucy Joshee1, Christy C Bridges2.   

Abstract

Methylmercury (CH3Hg+), a common environmental toxicant, has serious detrimental effects in numerous organ systems. We hypothesize that a significant physiological change, like pregnancy, can alter the disposition and accumulation of mercury. To test this hypothesis, pregnant and non-pregnant female Wistar rats were exposed orally to CH3Hg+. The amount of mercury in blood and total renal mass was significantly lower in pregnant rats than in non-pregnant rats. This finding may be due to expansion of plasma volume in pregnant rats and dilution of mercury, leading to lower levels of mercury in maternal blood and kidneys.

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Year:  2018        PMID： 29478229      PMCID： PMC6943925          DOI： 10.1007/s12011-018-1278-1

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  11 in total

1.  Some health physics aspects of working with 203Hg in university research.

Authors:  M Belanger; A Westin; D W Barfuss
Journal:  Health Phys       Date:  2001-02       Impact factor: 1.316

2.  Total mercury content in hair and neurologic signs: historic data from Minamata.

Authors:  Takashi Yorifuji; Toshihide Tsuda; Soshi Takao; Etsuji Suzuki; Masazumi Harada
Journal:  Epidemiology       Date:  2009-03       Impact factor: 4.822

Review 3.  The enigma of continual plasma volume expansion in pregnancy: critical role of the renin-angiotensin-aldosterone system.

Authors:  Crystal A West; Jennifer M Sasser; Chris Baylis
Journal:  Am J Physiol Renal Physiol       Date:  2016-10-05

4.  Elevated blood Hg at recommended seafood consumption rates in adult seafood consumers.

Authors:  Roxanne Karimi; Susan Silbernagel; Nicholas S Fisher; Jaymie R Meliker
Journal:  Int J Hyg Environ Health       Date:  2014-04-06       Impact factor: 5.840

5.  Placental and fetal disposition of mercuric ions in rats exposed to methylmercury: role of Mrp2.

Authors:  Christy C Bridges; Lucy Joshee; Rudolfs K Zalups
Journal:  Reprod Toxicol       Date:  2012-10-08       Impact factor: 3.143

6.  Mercury levels and fish consumption practices in women of child-bearing age in the Florida Panhandle.

Authors:  Natalie K Karouna-Renier; K Ranga Rao; John J Lanza; Samantha D Rivers; Patricia A Wilson; Denise K Hodges; Keith E Levine; Glenn T Ross
Journal:  Environ Res       Date:  2008-09-23       Impact factor: 6.498

7.  Effect of DMPS and DMSA on the placental and fetal disposition of methylmercury.

Authors:  C C Bridges; L Joshee; R K Zalups
Journal:  Placenta       Date:  2009-07-16       Impact factor: 3.481

8.  Multidrug resistance proteins and the renal elimination of inorganic mercury mediated by 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid.

Authors:  Christy C Bridges; Lucy Joshee; Rudolfs K Zalups
Journal:  J Pharmacol Exp Ther       Date:  2007-10-16       Impact factor: 4.030

9.  MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA.

Authors:  Rudolfs K Zalups; Christy C Bridges
Journal:  Toxicol Appl Pharmacol       Date:  2008-11-19       Impact factor: 4.219

10.  Blood volume changes in normal pregnancy.

Authors:  F Hytten
Journal:  Clin Haematol       Date:  1985-10
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