Leonardo Lorente1, María M Martín2, Pedro Abreu-González3, Rafael Sabatel4, Luis Ramos5, Mónica Argueso6, Jordi Solé-Violán7, Marta Riaño-Ruiz8, Alejandro Jiménez9, Victor García-Marín10. 1. Intensive Care Unit, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. Electronic address: lorentemartin@msn.com. 2. Intensive Care Unit, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain. 3. Department of Physiology, Faculty of Medicine, University of the La Laguna, Santa Cruz de Tenerife, Spain. 4. Department of Radiology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. 5. Intensive Care Unit, Hospital General La Palma, La Palma, Spain. 6. Intensive Care Unit, Hospital Clínico Universitario de Valencia, Valencia, Spain. 7. Intensive Care Unit, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain. 8. Servicio de Bioquímica Clínica, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Spain. 9. Research Unit, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. 10. Department of Neurosurgery, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
Abstract
OBJECTIVE: Oxidative stress has been associated with secondary brain injury after spontaneous intracerebral hemorrhage (SIH). Malondialdehyde (MDA) appears in blood during lipid oxidation. Higher serum MDA levels have been found in patients with SIH than in healthy controls; however, we have not found data indicating an association between elevated serum MDA and early mortality in this population. This was the main objective of our study. METHODS: MDA levels were measured in serum samples obtained from 100 patients at diagnosis of severe SIH (Glasgow Coma Scale score ≤8) and 80 healthy controls. The endpoint of the study was mortality at 30 days. RESULTS: Serum MDA levels were significantly higher in patients with severe SIH than in healthy controls (1.46 [1.18-2.2] vs. 1.11 [0.72-1.51]; P < 0.001), and in nonsurviving (n = 46) than in surviving (n = 54) patients (1.68 [1.23-4.02] vs. 1.37 [0.99-1.92]; P = 0.002). The area under the receiving operating characteristic curve of serum MDA levels to predict 30-day mortality was 0.68 (95% CI, 0.58-0.77; P < 0.001). Serum MDA levels were associated with 30-day mortality (OR, 6.279; 95% CI, 1.940-20.319; P = 0.002). CONCLUSIONS: The most important new finding of our study is that there is an association between serum MDA levels at diagnosis of severe SIH and early mortality.
OBJECTIVE: Oxidative stress has been associated with secondary brain injury after spontaneous intracerebral hemorrhage (SIH). Malondialdehyde (MDA) appears in blood during lipid oxidation. Higher serum MDA levels have been found in patients with SIH than in healthy controls; however, we have not found data indicating an association between elevated serum MDA and early mortality in this population. This was the main objective of our study. METHODS:MDA levels were measured in serum samples obtained from 100 patients at diagnosis of severe SIH (Glasgow Coma Scale score ≤8) and 80 healthy controls. The endpoint of the study was mortality at 30 days. RESULTS: Serum MDA levels were significantly higher in patients with severe SIH than in healthy controls (1.46 [1.18-2.2] vs. 1.11 [0.72-1.51]; P < 0.001), and in nonsurviving (n = 46) than in surviving (n = 54) patients (1.68 [1.23-4.02] vs. 1.37 [0.99-1.92]; P = 0.002). The area under the receiving operating characteristic curve of serum MDA levels to predict 30-day mortality was 0.68 (95% CI, 0.58-0.77; P < 0.001). Serum MDA levels were associated with 30-day mortality (OR, 6.279; 95% CI, 1.940-20.319; P = 0.002). CONCLUSIONS: The most important new finding of our study is that there is an association between serum MDA levels at diagnosis of severe SIH and early mortality.
Authors: Julia Masomi-Bornwasser; Elena Kurz; Christina Frenz; Jan Schmitt; Dominik M A Wesp; Jochem König; Johannes Lotz; Florian Ringel; Thomas Kerz; Harald Krenzlin; Naureen Keric Journal: Biomolecules Date: 2021-11-01
Authors: Leonardo Lorente; María M Martín; Pedro Abreu-González; Antonia Pérez-Cejas; Agustín F González-Rivero; Luis Ramos-Gómez; Mónica Argueso; Jordi Solé-Violán; Juan J Cáceres; Alejandro Jiménez; Victor García-Marín Journal: Brain Sci Date: 2020-03-26
Authors: Leonardo Lorente; María M Martín; Pedro Abreu-González; Luis Ramos; Mónica Argueso; Jordi Solé-Violán; Juan J Cáceres; Alejandro Jiménez; Victor García-Marín Journal: Brain Sci Date: 2019-10-01