Literature DB >> 29477591

Generation of a human induced pluripotent stem cell (iPSC) line from a 51-year-old female with attention-deficit/hyperactivity disorder (ADHD) carrying a duplication of SLC2A3.

Charline Jansch1, Katharina Günther2, Jonas Waider1, Georg C Ziegler1, Andrea Forero1, Sina Kollert3, Evgeniy Svirin4, Dirk Pühringer2, Chee Keong Kwok2, Reinhard Ullmann5, Anna Maierhofer6, Julia Flunkert6, Thomas Haaf6, Frank Edenhofer7, Klaus-Peter Lesch8.   

Abstract

Fibroblasts were isolated from a skin biopsy of a clinically diagnosed 51-year-old female attention-deficit/hyperactivity disorder (ADHD) patient carrying a duplication of SLC2A3, a gene encoding neuronal glucose transporter-3 (GLUT3). Patient fibroblasts were infected with Sendai virus, a single-stranded RNA virus, to generate transgene-free human induced pluripotent stem cells (iPSCs). SLC2A3-D2-iPSCs showed expression of pluripotency-associated markers, were able to differentiate into cells of the three germ layers in vitro and had a normal female karyotype. This in vitro cellular model can be used to study the role of risk genes in the pathogenesis of ADHD, in a patient-specific manner.
Copyright © 2018. Published by Elsevier B.V.

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Year:  2018        PMID： 29477591     DOI： 10.1016/j.scr.2018.02.005

Source DB:  PubMed          Journal:  Stem Cell Res        ISSN： 1873-5061            Impact factor:   2.020


  7 in total

1.  Promising Developments in the Use of Induced Pluripotent Stem Cells in Research of ADHD.

Authors:  Cristine Marie Yde Ohki; Rhiannon V McNeill; Matthias Nieberler; Franziska Radtke; Sarah Kittel-Schneider; Edna Grünblatt
Journal:  Curr Top Behav Neurosci       Date:  2022

2.  Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.

Authors:  Bo-Chul Shin; Carlos Cepeda; Mason Eghbali; Shin Yun Byun; Michael S Levine; Sherin U Devaskar
Journal:  Exp Neurol       Date:  2021-01-19       Impact factor: 5.330

3.  Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly.

Authors:  Charline Jansch; Georg C Ziegler; Andrea Forero; Sina Gredy; Sina Wäldchen; Maria Rosaria Vitale; Evgeniy Svirin; Johanna E M Zöller; Jonas Waider; Katharina Günther; Frank Edenhofer; Markus Sauer; Erhard Wischmeyer; Klaus-Peter Lesch
Journal:  J Neural Transm (Vienna)       Date:  2021-02-09       Impact factor: 3.575

4.  Transcript Analysis of Zebrafish GLUT3 Genes, slc2a3a and slc2a3b, Define Overlapping as Well as Distinct Expression Domains in the Zebrafish (Danio rerio) Central Nervous System.

Authors:  Carina G Lechermeier; Frederic Zimmer; Teresa M Lüffe; Klaus-Peter Lesch; Marcel Romanos; Christina Lillesaar; Carsten Drepper
Journal:  Front Mol Neurosci       Date:  2019-08-27       Impact factor: 5.639

Review 5.  A Link between Genetic Disorders and Cellular Impairment, Using Human Induced Pluripotent Stem Cells to Reveal the Functional Consequences of Copy Number Variations in the Central Nervous System-A Close Look at Chromosome 15.

Authors:  Alessia Casamassa; Daniela Ferrari; Maurizio Gelati; Massimo Carella; Angelo Luigi Vescovi; Jessica Rosati
Journal:  Int J Mol Sci       Date:  2020-03-09       Impact factor: 5.923

Review 6.  Mental health dished up-the use of iPSC models in neuropsychiatric research.

Authors:  Rhiannon V McNeill; Georg C Ziegler; Franziska Radtke; Matthias Nieberler; Klaus-Peter Lesch; Sarah Kittel-Schneider
Journal:  J Neural Transm (Vienna)       Date:  2020-05-07       Impact factor: 3.575

Review 7.  Making Sense of Patient-Derived iPSCs, Transdifferentiated Neurons, Olfactory Neuronal Cells, and Cerebral Organoids as Models for Psychiatric Disorders.

Authors:  Jakob Unterholzner; Vincent Millischer; Christoph Wotawa; Akira Sawa; Rupert Lanzenberger
Journal:  Int J Neuropsychopharmacol       Date:  2021-10-23       Impact factor: 5.176
  7 in total

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