Geng Zong1, Damaskini Valvi2, Brent Coull3, Thomas Göen4, Frank B Hu5, Flemming Nielsen6, Philippe Grandjean7, Qi Sun8. 1. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. 2. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. 3. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. 4. Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. 5. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States. 6. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States. 7. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States; Institute of Public Health, University of Southern Denmark, Odense, Denmark. 8. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States. Electronic address: qisun@hsph.harvard.edu.
Abstract
BACKGROUND: Exposure to persistent organic pollutants (POPs) may predispose to the development of type 2 diabetes (T2D), but prospective human evidence is scarce. OBJECTIVES: We investigated the association between plasma-POP concentrations in the late 1990s and incident T2D over 11 years of follow-up in the Nurses' Health Study II. DISCUSSION: Three organochlorine pesticides and 20 polychlorinated biphenyls (PCBs) were measured in banked plasma from 793 case-control pairs of T2D. In a multiviarate-adjusted model, T2D ORs (95%CIs) comparing extreme POP tertiles (high vs. low) were 1.67 (1.24, 2.23; Ptrend < 0.001) for hexachlorobenzene (HCB), 3.62 (2.57, 5.11; Ptrend < 0.001) for β-hexachlorocyclohexane (β-HCH), 1.55 (1.13, 2.13; Ptrend = 0.05) for p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), and 1.95 (1.42, 2.69; Ptrend < 0.001) for total dioxin-like PCBs (DL-PCBs) which included 5 mono-ortho congeners, PCB-105, 118, 156, 157, and 167. Adjustment for previous weight change and body mass index (BMI) at blood draw attenuated these associations, but that for DL-PCBs remained (OR[95% CI] = 1.78[1.14, 2.76]; Ptrend = 0.006). Age, breastfeeding history, previous weight change and BMI at blood draw were significant predictors of plasma POP concentrations. In addition, we found significant interactions of POPs and weight change before blood draw on T2D risk. ORs (95%CIs) of T2D comparing extreme (high vs. low) POP groups were 2.00 (1.02, 3.92; Ptrend = 0.01) for HCB, 2.69 (1.34, 5.40; Ptrend < 0.001) for β-HCH, and 2.41 (1.22, 4.77; Ptrend < 0.001) for DL-PCBs in the lowest weight gain group, whereas these values were 1.29 (0.73, 2.28; Ptrend = 0.46; Pinteraction = 0.04) for HCB, 1.41 (0.77, 2.60; Ptrend = 0.24; Pinteraction = 0.003) for β-HCH, and 0.90 (0.50, 1.63; Ptrend = 0.61; Pinteraction = 0.01) for DL-PCBs in the highest weight-gain group. CONCLUSIONS: Our findings suggest that elevated POP exposure may have diabetogenic potential. These data also highlight the impact of lifestyle factors, especially history of weight gain, on circulating POP concentrations and their associations with subsequent T2D risk.
BACKGROUND: Exposure to persistent organic pollutants (POPs) may predispose to the development of type 2 diabetes (T2D), but prospective human evidence is scarce. OBJECTIVES: We investigated the association between plasma-POP concentrations in the late 1990s and incident T2D over 11 years of follow-up in the Nurses' Health Study II. DISCUSSION: Three organochlorine pesticides and 20 polychlorinated biphenyls (PCBs) were measured in banked plasma from 793 case-control pairs of T2D. In a multiviarate-adjusted model, T2D ORs (95%CIs) comparing extreme POP tertiles (high vs. low) were 1.67 (1.24, 2.23; Ptrend < 0.001) for hexachlorobenzene (HCB), 3.62 (2.57, 5.11; Ptrend < 0.001) for β-hexachlorocyclohexane (β-HCH), 1.55 (1.13, 2.13; Ptrend = 0.05) for p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), and 1.95 (1.42, 2.69; Ptrend < 0.001) for total dioxin-like PCBs (DL-PCBs) which included 5 mono-ortho congeners, PCB-105, 118, 156, 157, and 167. Adjustment for previous weight change and body mass index (BMI) at blood draw attenuated these associations, but that for DL-PCBs remained (OR[95% CI] = 1.78[1.14, 2.76]; Ptrend = 0.006). Age, breastfeeding history, previous weight change and BMI at blood draw were significant predictors of plasma POP concentrations. In addition, we found significant interactions of POPs and weight change before blood draw on T2D risk. ORs (95%CIs) of T2D comparing extreme (high vs. low) POP groups were 2.00 (1.02, 3.92; Ptrend = 0.01) for HCB, 2.69 (1.34, 5.40; Ptrend < 0.001) for β-HCH, and 2.41 (1.22, 4.77; Ptrend < 0.001) for DL-PCBs in the lowest weight gain group, whereas these values were 1.29 (0.73, 2.28; Ptrend = 0.46; Pinteraction = 0.04) for HCB, 1.41 (0.77, 2.60; Ptrend = 0.24; Pinteraction = 0.003) for β-HCH, and 0.90 (0.50, 1.63; Ptrend = 0.61; Pinteraction = 0.01) for DL-PCBs in the highest weight-gain group. CONCLUSIONS: Our findings suggest that elevated POP exposure may have diabetogenic potential. These data also highlight the impact of lifestyle factors, especially history of weight gain, on circulating POP concentrations and their associations with subsequent T2D risk.
Authors: Philippe Grandjean; Jan Erik Henriksen; Anna L Choi; Maria Skaalum Petersen; Christine Dalgård; Flemming Nielsen; Pal Weihe Journal: Epidemiology Date: 2011-05 Impact factor: 4.822
Authors: Samuel P Caudill; Lee-Yang Wong; Wayman E Turner; Robin Lee; Alden Henderson; Donald G Patterson Journal: Chemosphere Date: 2007-01-30 Impact factor: 7.086
Authors: S Salvini; D J Hunter; L Sampson; M J Stampfer; G A Colditz; B Rosner; W C Willett Journal: Int J Epidemiol Date: 1989-12 Impact factor: 7.196
Authors: Duk-Hee Lee; Michael W Steffes; Andreas Sjödin; Richard S Jones; Larry L Needham; David R Jacobs Journal: Environ Health Perspect Date: 2010-05-05 Impact factor: 9.031
Authors: Richard Y Wang; Ram B Jain; Amy F Wolkin; Carol H Rubin; Larry L Needham Journal: Environ Health Perspect Date: 2009-03-12 Impact factor: 9.031
Authors: Anna Rignell-Hydbom; Jonas Lidfeldt; Hannu Kiviranta; Panu Rantakokko; Göran Samsioe; Carl-David Agardh; Lars Rylander Journal: PLoS One Date: 2009-10-19 Impact factor: 3.240
Authors: Kim Hooper; Jianwen She; Margaret Sharp; Joan Chow; Nicholas Jewell; Rosanne Gephart; Arthur Holden Journal: Environ Health Perspect Date: 2007-09 Impact factor: 9.031
Authors: Philip J Landrigan; John J Stegeman; Lora E Fleming; Denis Allemand; Donald M Anderson; Lorraine C Backer; Françoise Brucker-Davis; Nicolas Chevalier; Lilian Corra; Dorota Czerucka; Marie-Yasmine Dechraoui Bottein; Barbara Demeneix; Michael Depledge; Dimitri D Deheyn; Charles J Dorman; Patrick Fénichel; Samantha Fisher; Françoise Gaill; François Galgani; William H Gaze; Laura Giuliano; Philippe Grandjean; Mark E Hahn; Amro Hamdoun; Philipp Hess; Bret Judson; Amalia Laborde; Jacqueline McGlade; Jenna Mu; Adetoun Mustapha; Maria Neira; Rachel T Noble; Maria Luiza Pedrotti; Christopher Reddy; Joacim Rocklöv; Ursula M Scharler; Hariharan Shanmugam; Gabriella Taghian; Jeroen A J M van de Water; Luigi Vezzulli; Pál Weihe; Ariana Zeka; Hervé Raps; Patrick Rampal Journal: Ann Glob Health Date: 2020-12-03 Impact factor: 2.462
Authors: Michele A La Merrill; Caitlin L Johnson; Martyn T Smith; Namratha R Kandula; Anthony Macherone; Kurt D Pennell; Alka M Kanaya Journal: Environ Sci Technol Date: 2019-11-20 Impact factor: 9.028