Initialization of active contours for segmentation of breast cancer via fusion of ultrasound, Doppler, and elasticity images.

Active contours (snakes) are an efficient method for segmentation of ultrasound (US) images of breast cancer. However, the method produces inaccurate results if the seeds are initialized improperly (far from the true boundaries and close to the false boundaries). Therefore, we propose a novel initialization method based on the fusion of a conventional US image with elasticity and Doppler images. The proposed fusion method (FM) has been tested against four state-of-the-art initialization methods on 90 ultrasound images from a database collected by the Thammasat University Hospital of Thailand. The ground truth was hand-drawn by three leading radiologists of the hospital. The reference methods are: center of divergence (CoD), force field segmentation (FFS), Poisson Inverse Gradient Vector Flow (PIG), and quasi-automated initialization (QAI). A variety of numerical tests proves the advantages of the FM. For the raw US images, the percentage of correctly initialized contours is: FM-94.2%, CoD-0%, FFS-0%, PIG-26.7%, QAI-42.2%. The percentage of correctly segmented tumors is FM-84.4%, CoD-0%, FFS-0%, PIG-16.67%, QAI-22.44%. For reduced field of view US images, the percentage of correctly initialized contours is: FM-94.2%, CoD-0%, FFS-0%, PIG-65.6%, QAI-67.8%. The correctly segmented tumors are FM-88.9%, CoD-0%, FFS-0%, PIG-48.9%, QAI-44.5%. The accuracy, in terms of the average Hausdorff distance, is respectively 2.29 pixels, 33.81, 34.71, 7.7, and 8.4, whereas in terms of the Jaccard index, it is 0.9, 0.18, 0.19, 0.63, and 0.48.