Literature DB >> 2947708

The effect of nicotinamide on N-methyl-N'-nitro-N-nitrosoguanidine induced killing and mutation.

N Bhattacharyya, S B Bhattacharjee.   

Abstract

Nicotinamide, an inhibitor of poly(ADP-ribose) synthesis has been found to increase the killing of Chinese hamster V-79 cells induced by N-methyl-N'-nitro-N-nitrosoguanidine in concentration dependent manner. Such treatment also decreased the induced mutation. The nature of the results obtained was similar to those obtained earlier with benzamide, another inhibitor.

Entities:  

Mesh:

Substances:

Year:  1986        PMID: 2947708     DOI: 10.1016/0009-2797(86)90059-1

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN: 0009-2797            Impact factor:   5.192


  1 in total

1.  Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates alkylation-induced shuttle-vector mutagenesis in Chinese hamster cells.

Authors:  J Tatsumi-Miyajima; J H Küpper; H Takebe; A Bürkle
Journal:  Mol Cell Biochem       Date:  1999-03       Impact factor: 3.396

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.