Hans Pottel1, Elke Schaeffner2, Natalie Ebert2. 1. Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium. Electronic address: Hans.Pottel@kuleuven-kulak.be. 2. Charité Universitätsmedizin Berlin, Institute of Public Health, Berlin, Germany.
Abstract
BACKGROUND: Beta trace protein (BTP) is a novel renal biomarker that has emerged as potential alternative or addition to serum creatinine (Scr) and serum cystatin C (ScysC). We analyzed BTP's diagnostic ability to detect impaired kidney function by rescaling it and we tested whether rescaling BTP allowed us to expand the Full-Age-Spectrum (FAS)-equation to BTP. METHODS: 566 participants aged ≥70 years with measured glomerular filtration rate (mGFR), Scr, ScysC and BTP from the population-based Berlin Initiative Study (BIS) were considered. We developed a single and combined FAS-equation using rescaled BTP (BTP/0.60) and calculated its sensitivity (S) and specificity (Sp) to identify kidney disease using a fixed (60 mL/min/1.73 m2) and age-dependent threshold for mGFR. RESULTS: Rescaled BTP shared the same reference interval with rescaled Scr and ScysC and showed acceptable diagnostic performance (S = 73.1%, Sp = 86.5%), comparable to Scr (S = 71.0%, Sp = 90.5%) and ScysC (S = 80.7%, Sp = 92.9%). Rescaled BTP can be used in the FAS-equation with comparable performance as Scr and ScysC, but the Scr/ScysC/BTP-combined FAS-eq. (P10 = 57.8%, P30 = 96.6%) did not outperform the Scr/ScysC-combined FAS-eq. (P10 = 57.1%, P30 = 96.3%). CONCLUSIONS: Rescaled BTP is a valid alternative to Scr or ScysC to diagnose kidney function. The FAS-concept can be applied to BTP or the combination of BTP, Scr and ScysC.
BACKGROUND:Beta trace protein (BTP) is a novel renal biomarker that has emerged as potential alternative or addition to serum creatinine (Scr) and serum cystatin C (ScysC). We analyzed BTP's diagnostic ability to detect impaired kidney function by rescaling it and we tested whether rescaling BTP allowed us to expand the Full-Age-Spectrum (FAS)-equation to BTP. METHODS: 566 participants aged ≥70 years with measured glomerular filtration rate (mGFR), Scr, ScysC and BTP from the population-based Berlin Initiative Study (BIS) were considered. We developed a single and combined FAS-equation using rescaled BTP (BTP/0.60) and calculated its sensitivity (S) and specificity (Sp) to identify kidney disease using a fixed (60 mL/min/1.73 m2) and age-dependent threshold for mGFR. RESULTS: Rescaled BTP shared the same reference interval with rescaled Scr and ScysC and showed acceptable diagnostic performance (S = 73.1%, Sp = 86.5%), comparable to Scr (S = 71.0%, Sp = 90.5%) and ScysC (S = 80.7%, Sp = 92.9%). Rescaled BTP can be used in the FAS-equation with comparable performance as Scr and ScysC, but the Scr/ScysC/BTP-combined FAS-eq. (P10 = 57.8%, P30 = 96.6%) did not outperform the Scr/ScysC-combined FAS-eq. (P10 = 57.1%, P30 = 96.3%). CONCLUSIONS: Rescaled BTP is a valid alternative to Scr or ScysC to diagnose kidney function. The FAS-concept can be applied to BTP or the combination of BTP, Scr and ScysC.
Authors: Aino L Andersen; Morten B Houlind; Rikke L Nielsen; Lillian M Jørgensen; Charlotte Treldal; Morten Damgaard; Anne Kathrine Bengaard; Helle Gybel Juul-Larsen; Louise Bolvig Laursen; Esben Iversen; Marie Kruse; Anne M L Pedersen; Mads Hornum; Anne M Beck; Mette M Pedersen; Mikkel Z Ankarfeldt; Janne Petersen; Ove Andersen Journal: Trials Date: 2021-09-14 Impact factor: 2.279
Authors: Nan Chen; Hao Shi; Luxia Zhang; Li Zuo; Jingyuan Xie; Danshu Xie; Amy B Karger; Shiyuan Miao; Hong Ren; Wen Zhang; Weiming Wang; Yujing Pan; Wei Minji; Zhun Sui; Aghogho Okparavero; Andrew Simon; Juhi Chaudhari; John H Eckfeldt; Lesley A Inker; Andrew S Levey Journal: Kidney Med Date: 2020-01-31