Katerina Duskova1, Stepan Vesely2, Joana DO Carmo Silva2, Natalia Cernei3,4, Ondrej Zitka3,4, Zbynek Heger3,4, Vojtech Adam3,4, Klara Havlova2, Marek Babjuk2. 1. Department of Urology, Second Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic katerina.duskova@fnmotol.cz. 2. Department of Urology, Second Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic. 3. Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic. 4. Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic.
Abstract
BACKGROUND: Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of amino acids and the presence of urological tumors. MATERIALS AND METHODS: Using ion-exchange chromatography, we tested urine samples of patients with prostate cancer (n=30), urinary bladder cancer (n=28), renal cell carcinoma (n=16) and healthy volunteers (control group; n=21). RESULTS: In each category, we found a group of amino acids which differed in concentration compared to the control group. These differences were most significant in sarcosine in patients with prostate cancer; leucine, phenylalanine and arginine in those with bladder cancer; and sarcosine, glutamic acid, glycine, tyrosine and arginine in the those with renal cell carcinoma. CONCLUSION: Results of our research imply a possible connection between the occurrence of specific types of amino acids in the urine and the presence of urological tumors. Copyright
BACKGROUND: Insufficient specificity and invasiveness of currently used diagnostic methods raises the need for new markers of urological tumors. The aim of this study was to find a link between the urinary excretion of amino acids and the presence of urological tumors. MATERIALS AND METHODS: Using ion-exchange chromatography, we tested urine samples of patients with prostate cancer (n=30), urinary bladder cancer (n=28), renal cell carcinoma (n=16) and healthy volunteers (control group; n=21). RESULTS: In each category, we found a group of amino acids which differed in concentration compared to the control group. These differences were most significant in sarcosine in patients with prostate cancer; leucine, phenylalanine and arginine in those with bladder cancer; and sarcosine, glutamic acid, glycine, tyrosine and arginine in the those with renal cell carcinoma. CONCLUSION: Results of our research imply a possible connection between the occurrence of specific types of amino acids in the urine and the presence of urological tumors. Copyright
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