Selçuk Ozdogan1, Cumhur Kaan Yaltirik2, Seda Gulec Yilmaz3, Mustafa Kaya4, Ali Haluk Duzkalir5, Nail Demirel1, Ali Kafadar6, Turgay Isbir7. 1. Department of Neurosurgery, Istanbul Training and Research Hospital, Istanbul, Turkey. 2. Department of Neurosurgery, Yeditepe University Faculty of Medicine, Istanbul, Turkey. 3. Department of Molecular Medicine, Institute of Health Sciences, Yeditepe University, Istanbul, Turkey. 4. Department of Neurosurgery, Ereğli State Hospital, Zonguldak, Turkey. 5. Department of Neurosurgery, Dr.Lütfi Kırdar Kartal Training and Research Hospital, Istanbul, Turkey. 6. Department of Neurosurgery, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey. 7. Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey tur-gay.isbir@yeditepe.edu.tr tisbir@superonline.com.
Abstract
BACKGROUND/AIM: High-grade gliomas (HGG) consist of anaplastic oligoastrocytomas, anaplastic oligodendrogliomas, anaplastic astrocytomas and glioblastoma multiforme. The present study aimed to evaluate TNF-α -308 G>A polymorphism in a Turkish population. PATIENTS AND METHODS: This was a prospective case-control study that included 45 patients with HGG and 49 healthy individuals. All patients were operated for intracranial tumors and the pathology results consist of high grade (Grade3 and 4) glial tumors. RESULTS: No significant differences were found between the HGG and control groups in terms of the median age (p=0.898). There were no significant differences with regard to gender (p=0.577). The TNF genotype frequency comparison between patients and controls was not statistically significant (p=0.598). CONCLUSION: TNF genotype frequency comparison between the patients and controls was not statistically significant in the Turkish population tested. However, further studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities. Copyright
BACKGROUND/AIM: High-grade gliomas (HGG) consist of anaplastic oligoastrocytomas, anaplastic oligodendrogliomas, anaplastic astrocytomas and glioblastoma multiforme. The present study aimed to evaluate TNF-α -308 G>A polymorphism in a Turkish population. PATIENTS AND METHODS: This was a prospective case-control study that included 45 patients with HGG and 49 healthy individuals. All patients were operated for intracranial tumors and the pathology results consist of high grade (Grade3 and 4) glial tumors. RESULTS: No significant differences were found between the HGG and control groups in terms of the median age (p=0.898). There were no significant differences with regard to gender (p=0.577). The TNF genotype frequency comparison between patients and controls was not statistically significant (p=0.598). CONCLUSION:TNF genotype frequency comparison between the patients and controls was not statistically significant in the Turkish population tested. However, further studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities. Copyright
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