Literature DB >> 29475564

Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease.

David Weinshenker1.   

Abstract

It has been known for decades that degeneration of the locus coeruleus (LC), the major noradrenergic nucleus in the brain, occurs in both Alzheimer's disease (AD) and Parkinson's disease (PD), but it was given scant attention. It is now recognized that hyperphosphorylated tau in the LC is the first detectable AD-like neuropathology in the human brain, α-synuclein inclusions in the LC represent an early step in PD, and experimental LC lesions exacerbate neuropathology and cognitive/behavioral deficits in animal models. The purpose of this review is to consider the causes and consequences of LC pathology, dysfunction, and degeneration, as well as their implications for early detection and treatment.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Alzheimer’s disease; Parkinson’s disease; alpha-synuclein; locus coeruleus; tau

Mesh：

Substances：

Year:  2018        PMID： 29475564      PMCID： PMC5878728          DOI： 10.1016/j.tins.2018.01.010

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  141 in total

Review 1.  Where, when, and in what form does sporadic Alzheimer's disease begin?

Authors:  Heiko Braak; Kelly Del Tredici
Journal:  Curr Opin Neurol       Date:  2012-12       Impact factor: 5.710

Review 2.  Norepinephrine in depressive reactions. A review.

Authors:  W E Bunney; J M Davis
Journal:  Arch Gen Psychiatry       Date:  1965-12

3.  Synchronous activity in locus coeruleus results from dendritic interactions in pericoerulear regions.

Authors:  M Ishimatsu; J T Williams
Journal:  J Neurosci       Date:  1996-08-15       Impact factor: 6.167

4.  Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies.

Authors:  Patricia Szot; Sylvia S White; J Lynne Greenup; James B Leverenz; Elaine R Peskind; Murray A Raskind
Journal:  J Neurosci       Date:  2006-01-11       Impact factor: 6.167

5.  Differential degeneration of the locus coeruleus in dementia subtypes.

Authors:  H Brunnström; N Friberg; E Lindberg; E Englund
Journal:  Clin Neuropathol       Date:  2011 May-Jun       Impact factor: 1.368

Review 6.  Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders.

Authors:  Mathias Jucker; Lary C Walker
Journal:  Ann Neurol       Date:  2011-10       Impact factor: 10.422

Review 7.  Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.

Authors:  David Weinshenker; Philip V Holmes
Journal:  Brain Res       Date:  2015-11-20       Impact factor: 3.252

8.  Deep clinical and neuropathological phenotyping of Pick disease.

Authors:  David J Irwin; Johannes Brettschneider; Corey T McMillan; Felicia Cooper; Christopher Olm; Steven E Arnold; Vivianna M Van Deerlin; William W Seeley; Bruce L Miller; Edward B Lee; Virginia M-Y Lee; Murray Grossman; John Q Trojanowski
Journal:  Ann Neurol       Date:  2015-12-25       Impact factor: 10.422

9.  Caudo-rostral brain spreading of α-synuclein through vagal connections.

Authors:  Ayse Ulusoy; Raffaella Rusconi; Blanca I Pérez-Revuelta; Ruth E Musgrove; Michael Helwig; Bettina Winzen-Reichert; Donato A Di Monte
Journal:  EMBO Mol Med       Date:  2013-05-23       Impact factor: 12.137

10.  Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer's disease.

Authors:  Jacki M Rorabaugh; Termpanit Chalermpalanupap; Christian A Botz-Zapp; Vanessa M Fu; Natalie A Lembeck; Robert M Cohen; David Weinshenker
Journal:  Brain       Date:  2017-11-01       Impact factor: 15.255
View more
  64 in total

1.  Locus Coeruleus Degeneration Induces Forebrain Vascular Pathology in a Transgenic Rat Model of Alzheimer's Disease.

Authors:  Sarah C Kelly; Erin C McKay; John S Beck; Timothy J Collier; Anne M Dorrance; Scott E Counts
Journal:  J Alzheimers Dis       Date:  2019       Impact factor: 4.472

2.  A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents.

Authors:  Mattia Privitera; Kim David Ferrari; Lukas M von Ziegler; Oliver Sturman; Sian N Duss; Amalia Floriou-Servou; Pierre-Luc Germain; Yannick Vermeiren; Matthias T Wyss; Peter P De Deyn; Bruno Weber; Johannes Bohacek
Journal:  Nat Protoc       Date:  2020-07-06       Impact factor: 13.491

Review 3.  Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective.

Authors:  Paul J Derry; Muralidhar L Hegde; George R Jackson; Rakez Kayed; James M Tour; Ah-Lim Tsai; Thomas A Kent
Journal:  Prog Neurobiol       Date:  2019-10-08       Impact factor: 11.685

4.  Locus Coeruleus Phasic, But Not Tonic, Activation Initiates Global Remapping in a Familiar Environment.

Authors:  Stephanie L Grella; Jonathan M Neil; Hilary T Edison; Vanessa D Strong; Irina V Odintsova; Susan G Walling; Gerard M Martin; Diano F Marrone; Carolyn W Harley
Journal:  J Neurosci       Date:  2018-11-26       Impact factor: 6.167

5.  Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan.

Authors:  Martin J Dahl; Mara Mather; Myriam C Sander; Markus Werkle-Bergner
Journal:  J Neurosci       Date:  2020-04-21       Impact factor: 6.167

6.  Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease.

Authors:  Laura M Butkovich; Madelyn C Houser; Termpanit Chalermpalanupap; Kirsten A Porter-Stransky; Alexa F Iannitelli; Jake S Boles; Grace M Lloyd; Alexandra S Coomes; Lori N Eidson; Maria Elizabeth De Sousa Rodrigues; Danielle L Oliver; Sean D Kelly; Jianjun Chang; Nora Bengoa-Vergniory; Richard Wade-Martins; Benoit I Giasson; Valerie Joers; David Weinshenker; Malú Gámez Tansey
Journal:  J Neurosci       Date:  2020-08-31       Impact factor: 6.167

Review 7.  Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia.

Authors:  Filippo Sean Giorgi; Francesca Biagioni; Alessandro Galgani; Nicola Pavese; Gloria Lazzeri; Francesco Fornai
Journal:  Int J Mol Sci       Date:  2020-11-16       Impact factor: 5.923

8.  Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors.

Authors:  Paula K Zhu; W Sharon Zheng; Peng Zhang; Miao Jing; Philip M Borden; Farhan Ali; Kaiming Guo; Jiesi Feng; Jonathan S Marvin; Yali Wang; Jinxia Wan; Li Gan; Alex C Kwan; Li Lin; Loren L Looger; Yulong Li; Yajun Zhang
Journal:  Nano Lett       Date:  2020-05-12       Impact factor: 11.189

9.  Isometric exercise facilitates attention to salient events in women via the noradrenergic system.

Authors:  Mara Mather; Ringo Huang; David Clewett; Shawn E Nielsen; Ricardo Velasco; Kristie Tu; Sophia Han; Briana L Kennedy
Journal:  Neuroimage       Date:  2020-01-21       Impact factor: 6.556

10.  Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus.

Authors:  Seong Su Kang; Xia Liu; Eun Hee Ahn; Jie Xiang; Fredric P Manfredsson; Xifei Yang; Hongbo R Luo; L Cameron Liles; David Weinshenker; Keqiang Ye
Journal:  J Clin Invest       Date:  2020-01-02       Impact factor: 14.808
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.