Sir,We read an interesting letter by Kamath and Pemminati.[1] Here, we would like to share our view and experience:Methylcobalamin (MeCbl) or Vitamin B12 is many a times also used for radicular pain and many other nonspecific symptoms besides being used for its hematological and neurological disorders and neuropathies by registered medical practitioners, quacks, and general practitioners as an initial therapy before such patients are investigated or arrive to neurologists. At times, such patients do develop a habit of taking such treatments whenever they have recurrence of such symptomsOnce the MeCbl costing more and with other combinations entered the market, the pharmaceutical companies became successful in replacing it with cyanocobalamin by one or the other means. Many such combinations were ultimately banned by the Indian government very recentlyThe eminent authors have very well pointed out that there should be well-designed controlled trials comparing the various forms of Vitamin B12.