Literature DB >> 29472637

Impact of target interactions on small-molecule drug disposition: an overlooked area.

Robert A B van Waterschoot1, Neil J Parrott1, Andrés Olivares-Morales1, Thierry Lavé1, Malcolm Rowland2, Dennis A Smith3.   

Abstract

Mesh：

Year:  2018        PMID： 29472637     DOI： 10.1038/nrd.2018.26

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  10 in total

Review 1.  The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery.

Authors:  Dennis A Smith; Li Di; Edward H Kerns
Journal:  Nat Rev Drug Discov       Date:  2010-12       Impact factor: 84.694

2.  Use of microdosing to predict pharmacokinetics at the therapeutic dose: experience with 5 drugs.

Authors:  Graham Lappin; Wilhelm Kuhnz; Roeline Jochemsen; Johannes Kneer; Ajai Chaudhary; Berend Oosterhuis; Willem Jan Drijfhout; Malcolm Rowland; R Colin Garner
Journal:  Clin Pharmacol Ther       Date:  2006-09       Impact factor: 6.875

3.  Pharmacokinetic Steady-States Highlight Interesting Target-Mediated Disposition Properties.

Authors:  Johan Gabrielsson; Lambertus A Peletier
Journal:  AAPS J       Date:  2017-01-31       Impact factor: 4.009

Review 4.  Small-Molecule Compounds Exhibiting Target-Mediated Drug Disposition (TMDD): A Minireview.

Authors:  Guohua An
Journal:  J Clin Pharmacol       Date:  2016-09-06       Impact factor: 3.126

5.  Impact of a five-dimensional framework on R&D productivity at AstraZeneca.

Authors:  Paul Morgan; Dean G Brown; Simon Lennard; Mark J Anderton; J Carl Barrett; Ulf Eriksson; Mark Fidock; Bengt Hamrén; Anthony Johnson; Ruth E March; James Matcham; Jerome Mettetal; David J Nicholls; Stefan Platz; Steve Rees; Michael A Snowden; Menelas N Pangalos
Journal:  Nat Rev Drug Discov       Date:  2018-01-19       Impact factor: 84.694

Review 6.  Pharmacologic target-mediated drug disposition.

Authors:  G Levy
Journal:  Clin Pharmacol Ther       Date:  1994-09       Impact factor: 6.875

7.  Comparative pharmacokinetics of coumarin anticoagulants XLIV: Dose-dependent pharmacokinetics of warfarin in rats.

Authors:  K Takada; G Levy
Journal:  J Pharm Sci       Date:  1980-01       Impact factor: 3.534

8.  Comparative pharmacokinetics of coumarin anticoagulants. XLIX: Nonlinear tissue distribution of S-warfarin in rats.

Authors:  W K Cheung; G Levy
Journal:  J Pharm Sci       Date:  1989-07       Impact factor: 3.534

9.  Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans.

Authors:  Holger Fuchs; Jean-Paul Tillement; Saik Urien; Andreas Greischel; Willy Roth
Journal:  J Pharm Pharmacol       Date:  2009-01       Impact factor: 3.765

10.  Saturable tissue binding and imirestat pharmacokinetics in rats.

Authors:  J Y Chien; C R Banfield; R K Brazzell; P R Mayer; J T Slattery
Journal:  Pharm Res       Date:  1992-04       Impact factor: 4.200
  10 in total
  8 in total

Review 1.  Phase 0/microdosing approaches: time for mainstream application in drug development?

Authors:  Tal Burt; Graeme Young; Wooin Lee; Hiroyuki Kusuhara; Oliver Langer; Malcolm Rowland; Yuichi Sugiyama
Journal:  Nat Rev Drug Discov       Date:  2020-09-08       Impact factor: 84.694

2.  Impact of the selective A2AR and A2BR dual antagonist AB928/etrumadenant on CAR T cell function.

Authors:  Matthias Seifert; Mohamed-Reda Benmebarek; Daria Briukhovetska; Florian Märkl; Janina Dörr; Bruno L Cadilha; Jakob Jobst; Sophia Stock; David Andreu-Sanz; Theo Lorenzini; Ruth Grünmeier; Arman Oner; Hannah Obeck; Lina Majed; Dario Dhoqina; Manouk Feinendegen; Adrian Gottschlich; Jin Zhang; Ulrike Schindler; Stefan Endres; Sebastian Kobold
Journal:  Br J Cancer       Date:  2022-10-20       Impact factor: 9.075

Review 3.  Concept of Pharmacologic Target-Mediated Drug Disposition in Large-Molecule and Small-Molecule Compounds.

Authors:  Guohua An
Journal:  J Clin Pharmacol       Date:  2019-12-02       Impact factor: 3.126

4.  Target-Mediated Population Pharmacokinetic Modeling of Endothelin Receptor Antagonists.

Authors:  Anke-Katrin Volz; Jasper Dingemanse; Andreas Krause; Thorsten Lehr
Journal:  Pharm Res       Date:  2019-12-10       Impact factor: 4.200

5.  Simultaneous Target-Mediated Drug Disposition Model for Two Small-Molecule Compounds Competing for Their Pharmacological Target: Soluble Epoxide Hydrolase.

Authors:  Nan Wu; Bruce D Hammock; Kin Sing Stephen Lee; Guohua An
Journal:  J Pharmacol Exp Ther       Date:  2020-04-01       Impact factor: 4.030

6.  Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways.

Authors:  Kin Sing Stephen Lee; Jun Yang; Jun Niu; Connie J Ng; Karen M Wagner; Hua Dong; Sean D Kodani; Debin Wan; Christophe Morisseau; Bruce D Hammock
Journal:  ACS Cent Sci       Date:  2019-09-03       Impact factor: 14.553

Review 7.  Interpretation of Drug Interaction Using Systemic and Local Tissue Exposure Changes.

Authors:  Young Hee Choi
Journal:  Pharmaceutics       Date:  2020-05-02       Impact factor: 6.321

8.  Potential off-target effects of beta-blockers on gut hormone receptors: In silico study including GUT-DOCK-A web service for small-molecule docking.

Authors:  Pawel Pasznik; Ewelina Rutkowska; Szymon Niewieczerzal; Judyta Cielecka-Piontek; Dorota Latek
Journal:  PLoS One       Date:  2019-01-25       Impact factor: 3.240
  8 in total

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