| Literature DB >> 29471985 |
Andrew Xanthopoulos1, Filippos Triposkiadis2, Randall C Starling3.
Abstract
Heart failure (HF) is classified based upon the left ventricular ejection fraction (LVEF). Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disorder with increasing prevalence in the elderly that remains incompletely understood and inadequately treated as no therapy has shown favorable effects. In this review, we summarize the current theories regarding HFpEF pathogenesis, propose a phenotype-based classification of HFpEF, discuss prevention strategies, explain why clinical trials on HFpEF treatment have failed, and make suggestions for the future.Entities:
Keywords: Classification; Heart failure; Phenotypes; Preserved ejection fraction
Mesh:
Year: 2018 PMID: 29471985 DOI: 10.1016/j.tcm.2018.01.001
Source DB: PubMed Journal: Trends Cardiovasc Med ISSN: 1050-1738 Impact factor: 6.677