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Literature DB >> 29471566

Mucosal-Associated Invariant T Cells in Chronic Inflammatory Liver Disease.

Abstract

The broadening field of microbiome research has led to a substantial reappraisal of the gut-liver axis and its role in chronic liver disease. The liver is a central immunologic organ that is continuously exposed to food and microbial-derived antigens from the gastrointestinal tract. Mucosal-associated invariant T (MAIT) cells are enriched in the human liver and can be activated by inflammatory cytokines and microbial antigens. In chronic inflammatory liver disease, MAIT cells are depleted suggesting an impaired MAIT cell-dependent protection against bacterial infections. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2018 PMID： 29471566 PMCID： PMC6283052 DOI： 10.1055/s-0037-1621709

Source DB: PubMed Journal: Semin Liver Dis ISSN： 0272-8087 Impact factor: 6.115

55 in total

1. Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines.

Authors: Joana Dias; Edwin Leeansyah; Johan K Sandberg
Journal: Proc Natl Acad Sci U S A Date: 2017-06-19 Impact factor: 11.205

2. MR1 presents microbial vitamin B metabolites to MAIT cells.

Authors: Lars Kjer-Nielsen; Onisha Patel; Alexandra J Corbett; Jérôme Le Nours; Bronwyn Meehan; Ligong Liu; Mugdha Bhati; Zhenjun Chen; Lyudmila Kostenko; Rangsima Reantragoon; Nicholas A Williamson; Anthony W Purcell; Nadine L Dudek; Malcolm J McConville; Richard A J O'Hair; George N Khairallah; Dale I Godfrey; David P Fairlie; Jamie Rossjohn; James McCluskey
Journal: Nature Date: 2012-10-10 Impact factor: 49.962

3. Intra-Hepatic Depletion of Mucosal-Associated Invariant T Cells in Hepatitis C Virus-Induced Liver Inflammation.

Authors: Fabian J Bolte; Ashley C O'Keefe; Lauren M Webb; Elisavet Serti; Elenita Rivera; T Jake Liang; Marc Ghany; Barbara Rehermann
Journal: Gastroenterology Date: 2017-08-02 Impact factor: 22.682

Review 4. MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis.

Authors: Marielle C Gold; Ruth J Napier; David M Lewinsohn
Journal: Immunol Rev Date: 2015-03 Impact factor: 12.988

5. Decrease of CD69 levels on TCR Vα7.2⁺CD4⁺ innate-like lymphocytes is associated with impaired cytotoxic functions in chronic hepatitis B virus-infected patients.

Authors: Yean K Yong; Hong Y Tan; Alireza Saeidi; Mohamed Rosmawati; Nadia Atiya; Abdul W Ansari; Jayakumar Rajarajeswaran; Jamuna Vadivelu; Vijayakumar Velu; Marie Larsson; Esaki M Shankar
Journal: Innate Immun Date: 2017-06-13 Impact factor: 2.680

6. Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene.

Authors: P Riegert; V Wanner; S Bahram
Journal: J Immunol Date: 1998-10-15 Impact factor: 5.422

7. HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon.

Authors: Michael A Chattergoon; Rachel Latanich; Jeffrey Quinn; Matthew E Winter; Robert W Buckheit; Joel N Blankson; Drew Pardoll; Andrea L Cox
Journal: PLoS Pathog Date: 2014-05-01 Impact factor: 6.823

8. Mucosal-associated invariant T-cell frequency and function in blood and liver of HCV mono- and HCV/HIV co-infected patients with advanced fibrosis.

Authors: Boris J B Beudeker; Gertine W van Oord; Joop E Arends; Julian Schulze Zur Wiesch; Marieke S van der Heide; Robert J de Knegt; Annelies Verbon; Andre Boonstra; Mark A A Claassen
Journal: Liver Int Date: 2017-09-16 Impact factor: 5.828

9. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.

Authors: S Porcelli; C E Yockey; M B Brenner; S P Balk
Journal: J Exp Med Date: 1993-07-01 Impact factor: 14.307

10. Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells.

Authors: Rangsima Reantragoon; Alexandra J Corbett; Isaac G Sakala; Nicholas A Gherardin; John B Furness; Zhenjun Chen; Sidonia B G Eckle; Adam P Uldrich; Richard W Birkinshaw; Onisha Patel; Lyudmila Kostenko; Bronwyn Meehan; Katherine Kedzierska; Ligong Liu; David P Fairlie; Ted H Hansen; Dale I Godfrey; Jamie Rossjohn; James McCluskey; Lars Kjer-Nielsen
Journal: J Exp Med Date: 2013-10-07 Impact factor: 14.307

18 in total

Review 1. Insights From Antiviral Therapy Into Immune Responses to Hepatitis B and C Virus Infection.

Authors: Barbara Rehermann; Robert Thimme
Journal: Gastroenterology Date: 2018-09-26 Impact factor: 22.682

2. Alcohol-associated intestinal dysbiosis alters mucosal-associated invariant T-cell phenotype and function.

Authors: Min Gu; Derrick R Samuelson; Christopher M Taylor; Patricia E Molina; Meng Luo; Robert W Siggins; Judd E Shellito; David A Welsh
Journal: Alcohol Clin Exp Res Date: 2021-04-03 Impact factor: 3.455

Review 3. Innate immunity and HBV persistence.

Authors: Carolina Chiale; Anthony M Marchese; Michael D Robek
Journal: Curr Opin Virol Date: 2021-05-13 Impact factor: 7.121

Mucosal-Associated Invariant T Cells in Chronic Inflammatory Liver Disease.

1. Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines.

2. MR1 presents microbial vitamin B metabolites to MAIT cells.

3. Intra-Hepatic Depletion of Mucosal-Associated Invariant T Cells in Hepatitis C Virus-Induced Liver Inflammation.

Review 4. MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis.

5. Decrease of CD69 levels on TCR Vα7.2⁺CD4⁺ innate-like lymphocytes is associated with impaired cytotoxic functions in chronic hepatitis B virus-infected patients.

6. Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene.

7. HIV and HCV activate the inflammasome in monocytes and macrophages via endosomal Toll-like receptors without induction of type 1 interferon.

8. Mucosal-associated invariant T-cell frequency and function in blood and liver of HCV mono- and HCV/HIV co-infected patients with advanced fibrosis.

9. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.

10. Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells.

Review 1. Insights From Antiviral Therapy Into Immune Responses to Hepatitis B and C Virus Infection.

2. Alcohol-associated intestinal dysbiosis alters mucosal-associated invariant T-cell phenotype and function.

Review 3. Innate immunity and HBV persistence.

4. Mucosal-associated invariant T cells in hepatitis B virus-related liver failure.

Review 5. The Role of CD1d and MR1 Restricted T Cells in the Liver.

Review 6. The Differential Roles of T Cells in Non-alcoholic Fatty Liver Disease and Obesity.

Review 7. Incorporating mucosal-associated invariant T cells into the pathogenesis of chronic liver disease.

Review 8. Step by Step: Managing the Complications of Cirrhosis.

Review 9. Roles of Hepatic Innate and Innate-Like Lymphocytes in Nonalcoholic Steatohepatitis.

10. Fine needle aspirates comprehensively sample intrahepatic immunity.