Chun Liang Hsu1,2,3,4, John R Best1,2,3,4, Michelle W Voss5,6, Todd C Handy7, Olivier Beauchet8, Chris Lim1,2,3,4, Teresa Liu-Ambrose1,2,3,4. 1. Aging, Mobility, and Cognitive Neuroscience Lab, University of British Columbia, Vancouver, British Columbia, Canada. 2. Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada. 3. Djavad Mowafaghian Center for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada. 4. Center for Hip Health and Mobility, Vancouver, British Columbia, Canada. 5. Health, Brain, & Cognition Lab, University of Iowa, Iowa City. 6. Department of Psychology, University of Iowa, Iowa City. 7. Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada. 8. Geriatric Medicine, McGill University, Montreal, Quebec, Canada.
Abstract
BACKGROUND: Subtle, but observable, changes in mobility often exist among older adults with mild cognitive impairment (MCI). Notably, these changes are not inconsequential. Therefore, there is a strong interest to better understand the underlying neural correlates of gait slowing among older adults with MCI. In this study, we aimed to characterize patterns of functional connectivity associated with slower gait speed in older adults with MCI. METHODS: Forty-nine participants aged 60 years and older with MCI were included in the cross-sectional study. All participants underwent assessments of gait speed and resting state functional magnetic resonance imaging. RESULTS: In this sample of older adults with MCI, slower usual gait was characterized by altered connectivity between the sensorimotor network (SMN) and the frontoparietal network (FPN) (p < .05)-specifically, slower usual gait was associated with greater connectivity between the supplementary motor area (SMA) and the bilateral ventral visual cortices (p = .01); lower connectivity between the SMA and the bilateral superior lateral occipital cortex (p < .01); and lower connectivity between the SMA and the bilateral frontal eye field (p < .01). CONCLUSION: Altered inter-network functional connectivity between the SMN and FPN may be a neural mechanism for slowing of gait in older adults with MCI.
BACKGROUND: Subtle, but observable, changes in mobility often exist among older adults with mild cognitive impairment (MCI). Notably, these changes are not inconsequential. Therefore, there is a strong interest to better understand the underlying neural correlates of gait slowing among older adults with MCI. In this study, we aimed to characterize patterns of functional connectivity associated with slower gait speed in older adults with MCI. METHODS: Forty-nine participants aged 60 years and older with MCI were included in the cross-sectional study. All participants underwent assessments of gait speed and resting state functional magnetic resonance imaging. RESULTS: In this sample of older adults with MCI, slower usual gait was characterized by altered connectivity between the sensorimotor network (SMN) and the frontoparietal network (FPN) (p < .05)-specifically, slower usual gait was associated with greater connectivity between the supplementary motor area (SMA) and the bilateral ventral visual cortices (p = .01); lower connectivity between the SMA and the bilateral superior lateral occipital cortex (p < .01); and lower connectivity between the SMA and the bilateral frontal eye field (p < .01). CONCLUSION: Altered inter-network functional connectivity between the SMN and FPN may be a neural mechanism for slowing of gait in older adults with MCI.
Authors: Jan Adamczyk; Roman Celka; Rafał Stemplewski; Kinga Ceynowa; Paulina Kamińska; Janusz Maciaszek Journal: Biomed Res Int Date: 2020-07-01 Impact factor: 3.411
Authors: Deepthi Thumuluri; Robert Lyday; Phyllis Babcock; Edward H Ip; Robert A Kraft; Paul J Laurienti; Rebecca Barnstaple; Christina T Soriano; Christina E Hugenschmidt Journal: Front Sports Act Living Date: 2022-01-14